Fetal and fetal brain volume estimation in the third trimester of human pregnancy using gradient echo MR imaging
Fetal and fetal brain volume estimation in the third trimester of human pregnancy using gradient echo MR imaging
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DOI：
10.1016/s0730-725x(97)00281-6
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发表时间：
1998-04-01
影响因子：
2.5
通讯作者：
Whithouse, GH
中科院分区：
文献类型：
--
作者：
Gong, QY;Roberts, N;Whithouse, GH
应用卡瓦列里法联合梯度回声磁共振成像（MRI）研究妊娠晚期胎儿体积和胎儿脑容量的增加。研究招募了18名单胎孕妇。根据利物浦的数据，胎儿的出生体重都在10-90百分位之间。通过对每个体积估计值的误差系数进行加权的回归分析，发现在妊娠晚期，胎儿总体积与胎龄（R-2 = 0.88）、胎儿脑容量与胎龄（R-2 = 0.71）之间存在线性关系。胎儿体积平均每天增加25.2 ml，胎儿脑容量平均每天增加2.3 ml。在整个妊娠晚期，胎儿脑容量占胎儿总体积的比例平均保持恒定（10%,SD = 2%）。对8例诊断为异常的胎儿也获得了体积数据。8个异常胎儿中有7个的体积超出了正常胎儿数据所建立的95%置信区间。然而，在8个异常胎儿中，只有3个胎儿的脑容量超出了正常胎儿的95%置信区间，这可能是由于不对称生长迟缓时发生的脑保留。胎儿和胎儿脑的体积可以很容易地直接使用卡瓦列里方法和磁共振成像来估计。这些参数代表了评估胎儿生长的潜在有用信息。(C) 1998爱思唯尔科学有限公司
The Cavalieri method has been applied in combination with gradient echo magnetic resonance imaging (MRI) to investigate the increase in the volume of the fetus and fetal brain in the third trimester of pregnancy. Eighteen women with singleton pregnancies were recruited. Birthweights for the fetuses all lay within the 10-90th centile based on Liverpool data. A regression analysis, weighted using values derived from the coefficient of error predicted for each volume estimate, revealed a linear relationship between total fetal volume and gestational age (R-2 = 0.88) and between fetal brain volume and gestational age (R-2 = 0.71) during the third trimester. Fetal volume increased by an average of 25.2 ml per day and fetal brain volume increased by an average of 2.3 mL per day. Fetal brain volume is on average a constant proportion (10%, SD = 2%) of total fetal volume throughout the third trimester.Volume data were also obtained for eight fetuses diagnosed as abnormal. The volume of seven of the eight abnormal fetuses fell outside the 95% confidence interval established from the data obtained for the normal fetuses. However, for only three of the eight abnormal fetuses did brain volume fall outside the 95% confidence interval established for normals, possibly due to brain sparing occurring in asymmetrical growth retardation, The volume of the fetus and fetal brain may be readily estimated directly using the Cavalieri method and magnetic resonance imaging. These parameters represent potentially useful information for assessing fetal growth. (C) 1998 Elsevier Science Inc.