No association between a polymorphism in the steroid metabolism gene CYP17 and risk of breast cancer.
No association between a polymorphism in the steroid metabolism gene CYP17 and risk of breast cancer.
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DOI：
10.1038/bjc.1998.340
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发表时间：
1998-06
影响因子：
8.8
通讯作者：
Ponder, B A
中科院分区：
文献类型：
--
作者：
Dunning, A M;Healey, C S;Pharoah, P D;Foster, N A;Lipscombe, J M;Redman, K L;Easton, D F;Day, N E;Ponder, B A
最近的一项研究表明，在加利福尼亚州和夏威夷的亚裔、非裔美国人和拉丁裔女性中，CYP17基因启动子区域的T-->；C单碱基替换与乳腺癌风险和月经初潮年龄之间存在关联。C等位基因与乳腺癌风险的增加有关，在患有晚期疾病的患者中显著如此，而在对照组中，TT基因与月经初潮年龄较晚相关。我们试图在英格兰东安格利亚的一项大型病例对照研究中证实这些发现(835例病例和591名对照受试者)。我们没有发现C等位基因携带者患乳腺癌的风险[优势比(OR)1.10，可信区间(CI)0.89-1.37]或晚期乳腺癌(OR 0.88，CI 0.38-2.01)增加的证据，也没有证据表明初潮年龄和基因型之间存在任何关联。我们的结论是，这些等位基因不会显著改变英国人患乳腺癌的风险。
A recent study showed an association between a single base substitution, T-->C, in the promotor region of the CYP17 gene, the risk of breast cancer and age at menarche in Asian, African-American and Latino women from California and Hawaii. The C allele was associated with increased risk of breast cancer, significantly so for patients presenting with advanced disease, whereas the TT genotype was associated with later age at menarche in control subjects. We attempted to confirm these findings in a large case-control study in East Anglia, England (835 cases and 591 control subjects). We found no evidence of an increased risk of breast cancer [odds ratio (OR) 1.10, confidence interval (CI) 0.89-1.37] or advanced breast cancer (OR 0.88, CI 0.38-2.01) in C allele carriers, nor any association between age at menarche and genotype. We conclude that these alleles do not significantly alter breast cancer risk in the English population.