The reduction property for central polymorphisms in nonepistatic systems.
The reduction property for central polymorphisms in nonepistatic systems.
复制标题
非上位系统中中心多态性的还原性质。
DOI：
10.1016/0040-5809(82)90036-3
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发表时间：
1982
影响因子：
1.4
通讯作者：
Liberman,U
中科院分区：
文献类型：
--
作者：
Karlin,S;Liberman,U
乘法模型可以用作研究 n 位点选择机制的标准。该模型通过乘以与组成基因座相关的活力效应来确定基因型的适合度。当各个位点的适应度矩阵占主导地位时，多位点 Hardy-Weinberg (H-W) 多态性平衡的存在与重组结构无关。 Roux [参见 ABA 43, 567] 确定了这种多位点 H-W 多态性的稳定性条件。他观察到，当没有重组事件干扰时，2 位点稳定性条件足以实现总的多位点稳定性。本文表明，这种从n个基因座到2个基因座的还原特性不仅限于无干扰的重组机制，而且实际上适用于相当普遍的重组结构。
The multiplicative model can be used as a standard in studying n-locus selection regimes. This model determines the fitness of a genotype by multiplying the viability effects associated with the component loci. A multilocus Hardy-Weinberg (H-W) polymorphic equilibrium exists independent of the recombination structure when the fitness matrices of the individual loci are overdominant. Roux [see ABA 43, 567] determined the stability conditions for this multilocus H-W polymorphism. He observed that the 2-locus stability conditions are sufficient for the total multilocus stability when there is no interference for recombination events. It is shown in this paper that this reduction property, from n loci to 2 loci, is not limited to recombination mechanisms without interference, but in fact holds for quite general recombination structures.