Palladium-Catalyzed Reactions of Allylic Boronic Esters with Nucleophiles: Novel Umpolung Reactivity
Palladium-Catalyzed Reactions of Allylic Boronic Esters with Nucleophiles: Novel Umpolung Reactivity
复制标题
钯催化烯丙基硼酯与亲核试剂的反应：新型 Umpolung 反应性
作者：
Aggarwal V
氧化钯催化的反应条件已被开发，以允许区域选择性和立体选择性的偶联烯丙基硼酸酯与一系列的碳，氧，和氮基亲核试剂。对反应机理的研究表明，关键的金属转移步骤发生在保留立体化学的情况下，因为观察到了整体反转。
Oxidative palladium-catalyzed reaction conditions have been developed to allow for regioselective and stereoselective coupling of allylic boronic esters with a range of carbon-, oxygen-, and nitrogen-based nucleophiles. Studies into the mechanism of the reaction have shown that the key transmetalation step occurs with retention of stereochemistry, since overall inversion is observed.