Alterations of functional connectivity and intrinsic activity within the cingulate cortex of suicidal ideators.
Alterations of functional connectivity and intrinsic activity within the cingulate cortex of suicidal ideators.
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DOI：
10.1016/j.jad.2017.01.013
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发表时间：
2017-04-01
影响因子：
6.6
通讯作者：
Brent DA
中科院分区：
文献类型：
--
作者：
Chase HW;Segreti AM;Keller TA;Cherkassky VL;Just MA;Pan LA;Brent DA
“默认模式网络”（DMN）是包括后扣带皮层（PCC）在内的大脑区域的集合，在休息时显示出可靠的区域间功能连接。它与沉思和其他消极情感状态有关，但它在自杀意念中的作用还不清楚。我们采用基于种子的功能连接方法分析了34名自杀意念者和40名健康对照参与者的静息状态fMRI数据，以及感兴趣区域内的低频BOLD。还使用扩散张量成像（DTI）进行扣带束的结构成像。在两组之间，与背侧PCC或腹侧PCC的全脑连接大致完整，但尽管对照参与者显示背侧前扣带皮层（dACC）与背侧PCC之间的耦合大于dACC与腹侧PCC之间的耦合，但这种差异在意念者中逆转（T（72）=2.78，p=0.007）。此外，这三个区域（背侧、腹侧PCC、dACC）中的持续低频BOLD信号在意念中减少（F（1，72）=5.58，p=0.021）。扣带束的结构完整性也解释了功能连接措施的变化，但并没有消除组间差异。缺乏外部刺激或自我报告，阻止扣带连接的贡献，影响认知状态的推论。与临床变量的相关性均未达到校正显著性。这些研究结果提供了证据的DMN异常的自杀意念的倾向，支持参与扣带区以前牵连使用任务为基础的范例。
The ‘default mode network’ (DMN), a collection of brain regions including the posterior cingulate cortex (PCC), shows reliable inter-regional functional connectivity at rest. It has been implicated in rumination and other negative affective states, but its role in suicidal ideation is not well understood. We employed seed based functional connectivity methods to analyze resting state fMRI data in 34 suicidal ideators and 40 healthy control participants, as well as low frequency BOLD within the regions of interest. Structural imaging of the cingulum bundle was also conducted using diffusion tensor imaging (DTI). Whole-brain connectivity with dorsal PCC or ventral PCC was broadly intact between the two groups, but while the control participants showed greater coupling between the dorsal anterior cingulate cortex (dACC) and dorsal PCC, compared to the dACC and ventral PCC, this difference was reversed in the ideators (T(72)=2.78, p=0.007). Furthermore, ongoing low frequency BOLD signal in these three regions (dorsal, ventral PCC, dACC) was reduced in the ideators (F(1, 72)=5.58, p=0.021). The structural integrity of the cingulum bundle also explained variation in the functional connectivity measures but did not abolish the group differences. Lack of external stimulus or self-report prevents inferences about the contribution of cingulate connectivity to influence cognitive state. No associations with clinical variables reached corrected significance. These findings provide evidence of abnormalities in the DMN underlying the tendency towards suicidal ideation, supporting the involvement of cingulate regions previously implicated using task-based paradigms.