Risk factors for adenomyosis
Risk factors for adenomyosis
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DOI：
10.1093/humrep/12.6.1275
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发表时间：
1997-06-01
影响因子：
6.1
通讯作者：
Crosignani, PG
中科院分区：
文献类型：
--
作者：
Parazzini, F;Vercellini, P;Crosignani, PG
为了分析子宫腺肌病的危险因素，707名连续的妇女谁接受子宫切除术在1993年1月至1994年6月在Clinica Luigi Mangiagalii，米兰，意大利，在手术前接受采访的训练有素的医生。子宫腺肌症的信息来自病理记录。在707名女性中，150名受试者（21.2%）被确定为子宫腺肌病。吸烟的女性往往会降低患上这种疾病的风险：与从不吸烟的妇女相比，目前吸烟者的风险为0.7（0.3-1.3），风险随着每天吸烟数量的增加而降低，每天吸烟少于10支和多于10支的女性的比值比分别为0.8和0.6（卡方（2）趋势3.57，P = 0.06）。经产妇女子宫腺肌症的发生率较高：与初产妇女相比，报告一胎和二胎或多胎妇女子宫腺肌症的优势比分别为1.8（95% CI 0.9-3.4）和3.1（95% CI 1.7-5.5）（χ 2趋势20.71，P < 0.01）。同样，与未报告自然流产的妇女相比，报告一次或多次自然流产的妇女发生子宫腺肌病的优势比为1.7（95%CI 1.1-2.6）。
In order to analyse risk factors for adenomyosis, 707 consecutive women who underwent hysterectomy between January 1993 and June 1994 at the Clinica Luigi Mangiagalii, Milan, Italy, were interviewed before surgery by trained physicians. Information on the presence of adenomyosis was obtained from pathologic records. Out of the 707 women, adenomyosis was identified in 150 subjects (21.2%). Women who smoked tended to be at decreased risk of the condition: in comparison with women who had never smoked, the risk for current smokers was 0.7 (0.3-1.3) and the risk decreased with number of cigarettes smoked per day, the odds ratios being 0.8 and 0.6 respectively in women reporting fewer than 10 and more than 10 cigarette smoked per day (chi(2) trend 3.57, P = 0.06). The frequency of adenomyosis was higher in parous women: in comparison with nulliparae, the odds ratio of the disease were 1.8 [95% confidence interval (CI) 0.9-3.4] and 3.1 (95% CI 1.7-5.5) respectively in women reporting one and two or more births (chi(2) trend 20.71, P < 0.01). Likewise, women reporting one or more spontaneous abortions had an odds ratio of 1.7 (95% CI 1.1-2.6) for adenomyosis, in comparison with those reporting no spontaneous abortion.