Cardiac Tissue Engineering: Inclusion of Non-cardiomyocytes for Enhanced Features.
Cardiac Tissue Engineering: Inclusion of Non-cardiomyocytes for Enhanced Features.
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DOI：
10.3389/fcell.2021.653127
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发表时间：
2021
影响因子：
5.5
通讯作者：
Turnbull IC
中科院分区：
文献类型：
--
作者：
Munawar S;Turnbull IC
工程心脏组织 (ECT) 是心脏的 3D 生理模型，其在开发心血管疾病疗法和测试药物心脏毒性方面的潜在作用而被创建和研究。体外重建天然心肌的微环境主要涉及心肌细胞的使用。然而，与心肌细胞和非心肌细胞共培养构建的 ECT 相比，仅含有心肌细胞（仅 CM）的 ECT 通常表现较差，并且与天然心肌不太相似。共培养组织的一个重要目标是模仿天然心脏的细胞组成，这可以导致更好的组织功能和成熟度。在这篇综述中，我们研究了非肌细胞在 ECT 中的作用，并讨论了非肌细胞在增强 ECT 特征中的贡献机制。
Engineered cardiac tissues (ECTs) are 3D physiological models of the heart that are created and studied for their potential role in developing therapies of cardiovascular diseases and testing cardio toxicity of drugs. Recreating the microenvironment of the native myocardium in vitro mainly involves the use of cardiomyocytes. However, ECTs with only cardiomyocytes (CM-only) often perform poorly and are less similar to the native myocardium compared to ECTs constructed from co-culture of cardiomyocytes and nonmyocytes. One important goal of co-culture tissues is to mimic the native heart’s cellular composition, which can result in better tissue function and maturity. In this review, we investigate the role of nonmyocytes in ECTs and discuss the mechanisms behind the contributions of nonmyocytes in enhancement of ECT features.
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