METAL(LOID) LEVELS IN BIOLOGICAL MATRICES FROM HUMAN POPULATIONS EXPOSED TO MINING CONTAMINATION-PANASQUEIRA MINE (PORTUGAL)
METAL(LOID) LEVELS IN BIOLOGICAL MATRICES FROM HUMAN POPULATIONS EXPOSED TO MINING CONTAMINATION-PANASQUEIRA MINE (PORTUGAL)
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DOI：
10.1080/15287394.2012.690705
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发表时间：
2012-01-01
影响因子：
2.6
通讯作者：
Teixeira, Joao Paulo
中科院分区：
文献类型：
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作者：
Coelho, Patricia;Costa, Solange;Teixeira, Joao Paulo
采矿活动可能会影响居住在矿场附近的矿工和社区的健康，即使在矿场被废弃的情况下，这些健康影响也可能持续存在。在采矿过程中，会产生各种有毒废物，并释放到周围环境中，导致空气、饮用水、河流、植物和土壤受到污染。在葡萄牙中部Panasqueira矿区进行的一次地球化学采样活动中，在各种环境介质中发现了几种金属和砷(As)的异常分布。对居住在Panasqueira矿附近的一群人的血液、尿液、头发和指甲(脚趾和手指)中的砷、镉(Cd)、铬(Cr)、锰(Mn)、镍(Ni)、铅(Pb)和硒(Se)等几种潜在有害元素进行了定量测定，这些人在环境和职业上受到了暴露。还比较了一组人口统计特征相似但没有已知采矿活动的人群。通过T细胞受体(TCR)突变试验评价其遗传毒性，并选择不同淋巴细胞亚群的百分比作为免疫毒性生物标志物。电感耦合等离子体质谱(ICPMS)和电感耦合等离子体原子发射光谱分析(ICPAES)分析表明，与对照组相比，所有生物样本中As、Cd、Cr、Mn和Pb的水平都升高了。还观察了遗传毒性和免疫毒性的差异。这些结果提供了证据，表明采矿活动造成的环境和职业暴露增加了对人口健康的潜在风险。此外，结果强调需要为该区域实施预防措施、补救和恢复计划。
Mining activities may affect the health of miners and communities living near mining sites, and these health effects may persist even when the mine is abandoned. During mining processes various toxic wastes are produced and released into the surrounding environment, resulting in contamination of air, drinking water, rivers, plants, and soils. In a geochemical sampling campaign undertaken in the Panasqueira Mine area of central Portugal, an anomalous distribution of several metals and arsenic (As) was identified in various environmental media. Several potentially harmful elements, including As, cadmium (Cd), chromium (Cr), manganese (Mn), nickel (Ni), lead (Pb), and selenium (Se), were quantified in blood, urine, hair, and nails (toe and finger) from a group of individuals living near the Panasqueira Mine who were environmentally and occupationally exposed. A group with similar demographic characteristics without known exposure to mining activities was also compared. Genotoxicity was evaluated by means of T-cell receptor (TCR) mutation assay, and percentages of different lymphocyte subsets were selected as immunotoxicity biomarkers. Inductively coupled plasma-mass spectrometry (ICP-MS) and inductively coupled plasma-atomic emission spectrometry (ICP-AES) analysis showed elevated levels of As, Cd, Cr, Mn, and Pb in all biological samples taken from populations living close to the mine compared to controls. Genotoxic and immunotoxic differences were also observed. The results provide evidence of an elevated potential risk to the health of populations, with environmental and occupational exposures resulting from mining activities. Further, the results emphasize the need to implement preventive measures, remediation, and rehabilitation plans for the region.