Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathways.

Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathways.
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DOI:
10.1016/j.semcdb.2012.04.001
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发表时间:
2012-09
影响因子:
7.3
通讯作者:
Hemmings, Brian A.
Hemmings, Brian A.
中科院分区:
生物学2区
文献类型:
--
作者:
Hergovich, Alexander;Hemmings, Brian A.

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在过去的十年中,Hippo激酶信号传导已被确定为控制果蝇和哺乳动物组织生长的重要肿瘤抑制途径。Hippo核心信号盒的所有成员从酵母到人类都是保守的,因此Hippo、Mats和Lats的酵母类似物分别是出芽酵母和裂变酵母有丝分裂退出网络和分裂起始网络的核心组成部分。在这里,我们讨论了黑腹果蝇和哺乳动物的核心Hippo信号成分在多大程度上已经报告了与高度保守的酵母对应物相似的有丝分裂功能。
Over the past decade Hippo kinase signalling has been established as an essential tumour suppressor pathway controlling tissue growth in flies and mammals. All members of the Hippo core signalling cassette are conserved from yeast to humans, whereby the yeast analogues of Hippo, Mats and Lats are central components of the mitotic exit network and septation initiation network in budding and fission yeast, respectively. Here, we discuss how far core Hippo signalling components in Drosophila melanogaster and mammals have reported similar mitotic functions as already established for their highly conserved yeast counterparts.
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