Genome-wide phylogenetic and structural analysis reveals the molecular evolution of the ABA receptor gene family
Genome-wide phylogenetic and structural analysis reveals the molecular evolution of the ABA receptor gene family
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全基因组系统发育和结构分析揭示了 ABA 受体基因家族的分子进化。
DOI：
10.1093/jxb/erz511
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发表时间：
2020-02-07
影响因子：
6.9
通讯作者：
Yang，Guang-Fu
中科院分区：
文献类型：
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作者：
Yang，Jing-Fang;Chen，Mo-Xian;Yang，Guang-Fu
植物激素脱落酸（阿坝）在植物的生命周期以及对环境胁迫的适应性反应中起着至关重要的作用。ABA受体家族（Pyrabactin resistance 1/PYR 1-like/regulatory component of ABA receptor family，PYL）是目前已知最大的植物激素受体家族，是植物阿坝信号转导的核心调控元件。作为蛋白磷酸酶2C家族成员的负调节因子。由于PYLs在生物学上的重要性，许多研究者将注意力集中在它们的遗传冗余和随之而来的功能分化上。然而，很少有人了解它们的演变及其对监管多样性的产生的影响。本研究通过系统发育重建、基因结构和表达模式分析、正选择分析、功能分化分析和结构比较，对PYLs中的正选择和功能分化进行了鉴定。我们发现在分子识别结构域中的特定修饰下，PYLs的脱敏与功能多样化相关。因此，一个有趣的拮抗性的共同进化机制提出了阿坝受体家族蛋白的功能多样化。我们认为可能发生了一种补偿性进化途径。
The plant hormone abscisic acid (ABA) plays a crucial role during the plant life cycle as well as in adaptive responses to environmental stresses. The core regulatory components of ABA signaling in plants are the pyrabactin resistance1/PYR1-like/regulatory component of ABA receptor family (PYLs), which comprise the largest plant hormone receptor family known. They act as negative regulators of members of the protein phosphatase type 2C family. Due to the biological importance of PYLs, many researchers have focused on their genetic redundancy and consequent functional divergence. However, little is understood of their evolution and its impact on the generation of regulatory diversity. In this study, we identify positive selection and functional divergence in PYLs through phylogenetic reconstruction, gene structure and expression pattern analysis, positive selection analysis, functional divergence analysis, and structure comparison. We found the correlation of desensitization of PYLs under specific modifications in the molecular recognition domain with functional diversification. Hence, an interesting antagonistic co-evolutionary mechanism is proposed for the functional diversification of ABA receptor family proteins. We believe a compensatory evolutionary pathway may have occurred.