Probiotic supplementation does not improve eradication rate of Helicobacter pylori infection compared to placebo based on standard therapy: a meta-analysis.
Probiotic supplementation does not improve eradication rate of Helicobacter pylori infection compared to placebo based on standard therapy: a meta-analysis.
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与基于标准疗法的安慰剂相比，补充益生菌并不能提高幽门螺杆菌感染的根除率：一项荟萃分析
DOI：
10.1038/srep23522
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发表时间：
2016-03-21
影响因子：
4.6
通讯作者：
Yu C
中科院分区：
文献类型：
--
作者：
Lu C;Sang J;He H;Wan X;Lin Y;Li L;Li Y;Yu C
本荟萃分析纳入了符合条件的随机对照试验（rct），目的是确定补充益生菌是否能提高幽门螺杆菌根除率。检索PUBMED、EBSCO、Web of Science和Ovid数据库。我们纳入了调查益生菌与标准治疗联合或不联合安慰剂效果的随机对照试验。总共包括21项报告标准治疗加益生菌的随机对照试验。与安慰剂组相比，益生菌组在治疗意向分析（ITT）和方案分析（PP）中根除幽门螺杆菌感染的可能性分别为1.21（OR 1.21, 95% CI: 0.86, 1.69）和1.28 （OR 1.28, 95% CI: 0.88, 1.86）倍。与安慰剂组相比，三联治疗加14天疗程的益生菌并没有改善幽门螺杆菌感染的根除（OR: 1.44, 95% CI: 0.87, 2.39）。此外，与单独使用标准疗法相比，安慰剂加标准疗法并没有提高根除率（P = 0.816）。然而，益生菌确实改善了腹泻和恶心的不良反应。这些综合数据表明，与安慰剂相比，使用益生菌加标准治疗并不能提高幽门螺杆菌感染的根除率。
This meta-analysis included eligible randomized controlled trials (RCTs) with the aim of determining whether probiotic supplementation can improve H. pylori eradication rates. PUBMED, EBSCO, Web of Science and Ovid databases were searched. We included RCTs that investigated the effect of combining probiotics, with or without a placebo, with standard therapy. A total of 21 RCTs that reported standard therapy plus probiotics were included. Compared to the placebo group, the probiotics group was 1.21(OR 1.21, 95% CI: 0.86, 1.69) and 1.28 (OR 1.28, 95% CI: 0.88, 1.86) times more likely to achieve eradication of H. pylori infection in intent-to-treat (ITT) analysis and per protocol (PP) analysis, respectively. Probiotics with triple therapy plus a 14-day course of treatment did not improve the eradication of H. pylori infection (OR 1.44, 95% CI: 0.87, 2.39) compared to the placebo. Moreover, the placebo plus standard therapy did not improve eradication rates compared to standard therapy alone (P = 0.816). However, probiotics did improve the adverse effects of diarrhea and nausea. These pooled data suggest that the use of probiotics plus standard therapy does not improve the eradication rate of H. pylori infection compared to the placebo.