Effect of Dextran on Cerebral Function and Blood Flow after Cardiac Arrest. An Experimental Study on the Dog
Effect of Dextran on Cerebral Function and Blood Flow after Cardiac Arrest. An Experimental Study on the Dog
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右旋糖酐对心脏骤停后脑功能和血流的影响。
DOI：
10.1161/01.str.10.1.13
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发表时间：
1979
期刊：
影响因子：
8.3
通讯作者：
H. Fischer
中科院分区：
文献类型：
--
作者：
S. R. Lin;M. O’Connor;A. King;P. Harnish;H. Fischer
对 32 只戊巴比妥麻醉的杂种狗心脏骤停后 S 小时生存期间的脑电图活动和局部脑血流进行监测。对动物进行机械通气并将血气维持在生理水平。使用15n微球测量局部脑血流量和心输出量。使用双极技术从 6 个硬膜外电极记录 EEG。将动物分为3组。第一组的动物有8-11分钟的停留时间，第二组和第三组的动物有12-16分钟的停留时间。第二组动物不接受治疗。第III组动物在被捕后给予1g/kg浓度为10%的生理盐水中的葡聚糖40，并在恢复的5小时期间维持10mg/kg/min。在第一组和第三组中，平坦脑电图的持续时间较短，并且在逮捕后 5 小时，脑电图活动比第二组更接近正常。 5小时后，第III组的脑电图评分显着高于第II组（p < 0.03）。心脏骤停后，皮质灰质和海马体的血流量减少最多。 3小时时，II组的平均皮质灰质血流量低于I组和III组。 5小时后，第III组的灰质血流量大于第II组(p < 0.09)。这项研究的结果与以下假设一致：心脏骤停后，血压恢复后灌注异常持续存在或发展，并且可以通过在心脏骤停后用右旋糖酐 40 治疗来纠正或预防这些异常，从而改善功能生存。
EEG activity and regional cerebral blood flow were monitored during S hour survival following cardiac arrest in 32 pentobarbital anesthetized mongrel dogs. The animals were mechanically ventilated and blood gases were maintained at physiologic levels. Regional cerebral blood flow and cardiac output were measured using 15 n microspheres. EEG was recorded from 6 epidural electrodes using bipolar techniques. The animals were divided into 3 groups. The animals in Group I had an arrest of 8-11 minutes and those in Group II and III had an arrest of 12-16 minutes. Group II animals received no treatment. Group III animals were given 1 g/kg of dextran 40 at a concentration of 10% in normal saline following the arrest and maintained with 10 mg/kg/min during the 5 hours of recovery. In Groups I and III there was shorter duration of a flat EEG and 5 hours after the arrest the EEG activity was closer to normal than in Group II. After 5 hours the EEG scores of Group III were significantly greater than Group II (p < 0.03). The cortical grey matter and hippocampus had the greatest reduction of blood flow following cardiac arrest. The mean cortical grey matter blood flow in Group II was less than in Groups I and III at 3 hours. After 5 hours the grey matter blood flow was greater in Group III than in Group II (p < 0.09). The findings of this study are consistent with the hypothesis that after cardiac arrest perfusion abnormalities persist or develop after return of blood pressure and that these can be corrected or prevented with improved functional survival by treatment with dextran 40 after the arrest.