Edible Lily Bulb Modulates Colonic Barrier Functions, Microflora and Fermentation in Rats Fed a High-Fat Diet
Edible Lily Bulb Modulates Colonic Barrier Functions, Microflora and Fermentation in Rats Fed a High-Fat Diet
复制标题
食用百合调节高脂肪饮食大鼠的结肠屏障功能、微生物区系和发酵
DOI：
10.15226/jnhfs.2014.00112
复制
发表时间：
2014
影响因子：
13.6
通讯作者：
N. Kato
中科院分区：
文献类型：
--
作者：
Y. Okazaki;E. Fukuda;H. Chiji;N. Kato
Lily bulb (Lilium leichtlinii var. maximowiczii Baker) is traditionally consumed in Asia as both a root vegetable and a herbal medicine. The objective of this study was to determine if dietary edible lily bulbs modulated the colonic luminal environment in rats fed a high-fat (HF) diet. In experiment 1, male SD rats were fed a HF diet (30% beef tallow) with or without 5% or 10% raw lily bulb powder for 3 weeks. Dietary raw lily bulb significantly increased cecal and fecal mucins, IgA (indices of intestinal barrier and immune functions) and the cecal ratio of Lactobacillales and Bifidobacterium in a dose-dependent manner. In experiment 2, the rats were fed a HF diet with or without 7% steamed or raw lily bulb powder for 3 weeks. Cecal ratio of Lactobacillales was significantly increased in the HF + raw lily bulb group, with a similar trends being observed in the HF + steamed lily bulb group. Consumption of both steamed and raw lily bulb caused markedly increases in cecal and fecal mucins and cecal organic acids, including lactate, propionate, acetate, and butyrate. Unexpectedly, HF + steamed lily bulb diet caused a significant reduction in the fecal activity of mucinase, a risk factor for colon diseases, and mesenteric adipose tissue weight, whereas the HF + raw lily bulb diet did not. These results suggest a favorable effect of lily bulb on colon health by modulating colonic barrier function, microflora profile, and fermentation in rats fed a high-fat diet.
DOI：
10.1073/pnas.0504978102
发表时间：
2005-08-02
影响因子：
11.1
作者：
Ley, RE;Bäckhed, F;Gordon, JI
通讯作者：
Gordon, JI