Increased Endothelial Progenitor Cells and Nitric Oxide in Young Prehypertensive Women
Increased Endothelial Progenitor Cells and Nitric Oxide in Young Prehypertensive Women
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年轻高血压前期女性的内皮祖细胞和一氧化氮增加
DOI：
10.1111/jch.12493
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发表时间：
2015-04-01
影响因子：
2.8
通讯作者：
Zeng, Haitao
中科院分区：
文献类型：
--
作者：
Zhen, Yang;Xiao, Songhua;Zeng, Haitao
本研究探讨了高血压前期性别差异对循环内皮祖细胞（EPC）的影响及其潜在机制。作者发现，与男性相比，绝经前女性的循环 EPC 数量和活性有所增加，这与血浆或培养基中一氧化氮 (NO) 水平的增加类似。血压正常和高血压前期绝经前妇女之间循环 EPC 的数量和活性以及 NO 水平没有差异。血管内皮生长因子和粒细胞巨噬细胞集落刺激因子的水平也没有发现差异。循环EPCs的数量和活性均与NO水平相关。本研究首次证明了高血压前期绝经前女性循环EPCs的数量和活性得以保留，这与NO生成的恢复有关。高血压前期EPCs的性别差异可能与绝经前女性血管保护机制有关。 (C) 2015 年 Wiley 期刊公司。
This study investigated the effect of sex differences on circulating endothelial progenitor cells (EPCs) in prehypertension and its underlying mechanism. The authors found that premenopausal women show increased number and activity of circulating EPCs when compared with men, which was similar to enhanced nitric oxide (NO) level in plasma or culture medium. There was no difference in the number and activity of circulating EPCs and NO level between normotensive and prehypertensive premenopausal women. There was also no difference seen in levels of vascular endothelial growth factor and granulocyte macrophage colony-stimulating factor. Both number and activity of circulating EPCs were correlated with the level of NO. The present study firstly demonstrated that the number and activity of circulating EPCs were preserved in prehypertensive premenopausal women, which was related to the restoration of NO production. The sex differences in EPCs in prehypertension may be involved in the mechanism underlying vascular protection in premenopausal women. (C) 2015 Wiley Periodicals, Inc.