Biomaterials for enhancing anti-cancer immunity.
Biomaterials for enhancing anti-cancer immunity.
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生物材料可增强抗癌免疫力。
DOI：
10.1016/j.copbio.2016.02.001
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发表时间：
2016-08
影响因子：
7.7
通讯作者：
Mooney DJ
中科院分区：
文献类型：
--
作者：
Koshy ST;Mooney DJ
癌症免疫疗法正在成为治疗许多癌症的标准方法。然而，目前方法的缺点限制了许多患者的治疗益处。合理设计的生物材料策略来递送免疫调节药物可以潜在地显示出改善的安全性，同时向免疫细胞提供多功能和时空控制的信号以改善其抗癌活性。这篇简短的综述描述了基于生物材料的策略，这些策略增强了各种组织部位的免疫细胞功能，以提高抗癌免疫力。生物工程师，免疫学家，工业和临床医生之间的持续合作是基于生物材料的免疫治疗策略继续走向临床所必需的。
Cancer immunotherapy is becoming a standard approach to treat many cancers. However, shortcomings of current methods limit therapeutic benefit in many patients. Rationally designed biomaterial strategies to deliver immune modulatory drugs can potentially show improved safety profiles, while providing multifunctional and spatiotemporally controlled signals to immune cells to improve their anti-cancer activity. This brief review describes biomaterials-based strategies that enhance immune cell function at various tissue sites to improve anti-cancer immunity. Continued collaboration between bioengineers, immunologists, industry, and clinicians is required for biomaterial-based immunotherapy strategies to continue moving to the clinic.