Epidemics to eradication: the modern history of poliomyelitis.
Epidemics to eradication: the modern history of poliomyelitis.
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DOI：
10.1186/1743-422x-4-70
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发表时间：
2007-07-10
期刊：
影响因子：
4.8
通讯作者：
De Jesus NH
中科院分区：
文献类型：
--
作者：
De Jesus NH
脊髓灰质炎自古以来就困扰着人类，近一个世纪以来，我们都知道其病原体——脊髓灰质炎病毒。这种病原体是一种肠道病毒，在近代史上一直是人类遭受巨大痛苦的根源。尽管其基因组相对较小，但其基因组中充满了足够的信息，使其成为一种可怕的病原体。在过去的 20 年里，全球根除脊髓灰质炎行动已被证明成功地大大减少了全世界的病例数量，但在其实施过程中遇到了障碍，导致阻止野生脊髓灰质炎病毒的传播实际上是不可能的。当我们开始意识到战略的改变可能对于这一事业取得成功至关重要时，我们必须批判性地评估对这种病原体的分子生物学及其与宿主相互作用的复杂性的了解，以便在未来的尝试中我们可以更好地准备更有效地对抗这种重要的人类病原体。
Poliomyelitis has afflicted humankind since antiquity, and for nearly a century now, we have known the causative agent, poliovirus. This pathogen is an enterovirus that in recent history has been the source of a great deal of human suffering. Although comparatively small, its genome is packed with sufficient information to make it a formidable pathogen. In the last 20 years the Global Polio Eradication Initiative has proven successful in greatly diminishing the number of cases worldwide but has encountered obstacles in its path which have made halting the transmission of wild polioviruses a practical impossibility. As we begin to realize that a change in strategy may be crucial in achieving success in this venture, it is imperative that we critically evaluate what is known about the molecular biology of this pathogen and the intricacies of its interaction with its host so that in future attempts we may better equipped to more effectively combat this important human pathogen.