Development of pH-Responsive Core-Shell Microcapsule Reactor
Development of pH-Responsive Core-Shell Microcapsule Reactor
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pH响应型核壳微胶囊反应器的研制
DOI：
10.11491/apcche.2004.0.61.0
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Takeo Yamaguchi
中科院分区：
文献类型：
--
作者：
Kazuki Akamatsu;Takeo Yamaguchi
研制了一种新型智能微胶囊反应器系统。该反应器能识别介质中的pH变化，并能自行控制反应速率。反应器系统选用丙烯酸（AA）、n -异丙基丙烯酰胺（NIPAM）和葡萄糖氧化酶（GOD）分别作为ph响应装置、门控装置和反应装置。聚（NIPAM-co-AA） （P-NIPAM-co-AA）的亲疏水性会因pH值的变化而改变。它们被整合在一个核壳微胶囊中。采用等离子体接枝填充聚合的方法，将GOD加载到核心空间内，并在外壳层的孔隙中填充P-NIPAM-co-AA线性接枝链作为ph响应门。在高pH值下，P-NIPAM-co-AA门具有亲水性，微胶囊允许葡萄糖渗透到核心空间并进行GOD反应。另一方面，在低pH值下，P-NIPAM-co-AA门是疏水的，微胶囊阻止葡萄糖渗透，不会发生GOD反应。对这一概念的准确性进行了检验。
A novel type of intelligent microcapsule reactor system was prepared. This reactor can recognize pH change in the media and control reaction rate by itself. For the reactor system, acrylic acid (AA), N-isopropylacrylamide (NIPAM), and glucose oxidase (GOD) were selected as a pH-responsive device, a gating device and a reaction device, respectively. Poly(NIPAM-co-AA) (P-NIPAM-co-AA) is known to change its hydrophilicity-hydrophobicity due to pH change. They were integrated in a core-shell microcapsule. GOD was loaded inside the core space and the pores in the outside shell layer were filled with P-NIPAM-co-AA linear grafted chains as pH-responsive gates by plasma graft filling polymerization method. At high pH value, the P-NIPAM-co-AA gates are hydrophilic and the microcapsule permits glucose penetration into the core space and GOD reaction proceeds. On the other hand, at low pH value, the P-NIPAM-co-AA gates are hydrophobic and the microcapsule prevents glucose penetration, resulting no GOD reaction. The accuracy of this concept was examined.