p53 Regulation of Metabolic Pathways
p53 Regulation of Metabolic Pathways
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DOI：
10.1101/cshperspect.a001040
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发表时间：
2010-04-01
影响因子：
7.2
通讯作者：
Vousden, Karen H.
中科院分区：
文献类型：
--
作者：
Gottlieb, Eyal;Vousden, Karen H.
在肿瘤发生过程中，细胞获得许多有助于获得恶性表型的改变，使它们能够在日益恶劣的环境中生存和繁荣。癌细胞的特征可以是细胞增殖和生长控制的扰动、对死亡的抵抗以及它们与微环境相互作用的改变。这些变化的基础是新陈代谢的变化，使癌细胞能够使用替代途径来产生能量，构建生长所需的大分子，以及调节信号分子（如活性氧（ROS））的产生。在过去的几年里，人们清楚地认识到，p53，即使不是最重要的，也是研究最多的肿瘤抑制蛋白，也可以直接控制细胞的代谢特性。
During the course of tumorigenesis, cells acquire a number of alterations that contribute to the acquisition of the malignant phenotype, allowing them to survive and flourish in increasingly hostile environments. Cancer cells can be characterized by perturbations in the control of cell proliferation and growth, resistance to death, and alterations in their interactions with the microenvironment. Underpinning many of these changes are shifts in metabolism that allow cancer cells to use alternative pathways for energy production and building the macromolecules necessary for growth, as well as regulating the generation of signaling molecules such as reactive oxygen species (ROS). In the past few years, it became clear that p53, the most studied, if not most important, tumor suppressor protein, can also directly control metabolic traits of cells.