NeuroImage: Clinical Cortical thickness atrophy in the transentorhinal cortex in mild cognitive impairment
NeuroImage: Clinical Cortical thickness atrophy in the transentorhinal cortex in mild cognitive impairment
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本研究检查了轻度认知障碍（MCI）受试者与对照组相比，内侧颞叶内四个区域的萎缩率：经内嗅皮层（TEC），内嗅皮层（ERC），海马和杏仁核。这些区域被手动分割，然后通过基于大变形度量映射（LDDMM）的纵向变形测量来校正不期望的长期变化。采用微分形态测量技术比较TEC和ERC中的厚度测量值。TEC的厚度萎缩率比内嗅皮质的内侧区域有更显著的变化。还计算了所有四个区域的数量。使用线性判别分析构建分类器，以证明与检查区域的厚度和体积测量相比，TEC的平均厚度和萎缩率是区分MCI与对照的最具区分力的测量。这些发现与尸检结果一致，表明在TEC中发现了初始神经元变化，然后在ERC中向内侧扩散，并扩散到内侧颞叶的其他区域。这些发现表明，TEC厚度可以作为阿尔茨海默病前驱期的生物标志物。
This study examines the atrophy rates of subjects with mild cognitive impairment (MCI) compared to controls in four regions within the medial temporal lobe: the transentorhinal cortex (TEC), entorhinal cortex (ERC), hippocampus, and amygdala. These regions were manually segmented and then corrected for undesirable long- itudinal variability via Large Deformation Di ff eomorphic Metric Mapping (LDDMM) based longitudinal di ff eomorphometry. Di ff eomorphometry techniques were used to compare thickness measurements in the TEC with the ERC. There were more signi fi cant changes in thickness atrophy rate in the TEC than medial regions of the entorhinal cortex. Volume measures were also calculated for all four regions. Classi fi ers were constructed using linear discriminant analysis to demonstrate that average thickness and atrophy rate of TEC together was the most discriminating measure compared to the thickness and volume measures in the areas examined, in di ff er- entiating MCI from controls. These fi ndings are consistent with autopsy fi ndings demonstrating that initial neuronal changes are found in TEC before spreading more medially in the ERC and to other regions in the medial temporal lobe. These fi ndings suggest that the TEC thickness could serve as a biomarker for Alzheimer's disease in the prodromal phase of the disease.