Evaluations of Corneas in Eyes with Isolated Iris Coloboma
Evaluations of Corneas in Eyes with Isolated Iris Coloboma
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DOI：
10.3109/02713683.2016.1151054
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发表时间：
2017-01-01
影响因子：
2
通讯作者：
Zararsiz, Gokmen
中科院分区：
文献类型：
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作者：
Hashas, Arzu Seyhan Karatepe;Arifoglu, Hasan Basri;Zararsiz, Gokmen
目的：我们旨在评估孤立性虹膜缺损眼角膜的差异。方法：本研究是一项前瞻性研究。在近3年内向我院提出申请的患者中，其中一只眼睛患有孤立性虹膜缺损且对侧眼睛完全正常的患者被纳入研究。除了完整的眼科检查外，所有患者均在黑暗中使用 Pentacam Scheimpflug 相机进行扫描，并使用 Topcon 镜面显微镜进行角膜内皮细胞计数。然后通过配对 t 检验评估使用 SPSS 软件输入的数据； p < 0.05 值被认为具有统计学意义。 结果：本研究纳入 9 名患者，其中 7 名男性和 2 名女性，平均年龄为 35.77±22.50（范围 8-60）岁。与正常眼睛相比，统计发现缺损眼的屈光度较低（43.82 +/- 2.17、44.46 +/- 1.86；p = 0.040）、负非球面度（Q 值）更大（-0.38 +/- 0.07、-0.22 +/- 0.20；p = 0.042）、角膜增大厚度（569.78 +/- 25.42、537.33 +/- 27.36；p < 0.001）、前房深度减小（2.50 +/- 0.32、2.81 +/- 0.50；p = 0.005）、角度较浅（30.51 +/- 10.68、35.29 +/- 9.99；p = 0.057)，角膜前表面和后表面的最佳拟合球面 (BFS) 值更高（7.88 +/- 0.39、7.67 +/- 0.37；p = 0.001；6.40 +/- 0.26、6.23 +/- 0.19；p = 0.006）、瞳孔直径更大（3.48 +/- 0.49、 2.80 +/- 0.34；p = 0.001），较小的水平角膜直径（HCD）（11.06 +/- 0.42；11.26 +/- 0.45；p = 0.009），以及较高的内皮细胞密度（ECD）值（3161 +/- 431；2923 +/- 590；p = 0.031）。结论：我们已经确定许多因素（例如角膜曲率测量值，尤其是角膜内皮的角膜曲率值）与正常眼睛的不同。在虹膜缺损眼的随访和治疗中应考虑到这些差异。
Purpose: We aimed to evaluate the differences in the corneas of eyes with isolated iris coloboma.Methods: This study was designed as a prospective study. Among patients who applied to our hospital within the last 3-year period, those with isolated iris coloboma in one eye and a completely normal contralateral eye were included in the study. In addition to a complete ophthalmologic examination, all patients were scanned by Pentacam Scheimpflug camera in the dark, and a corneal endothelium cell count was taken using a Topcon Specular Microscope. Data entered using SPSS software were then evaluated by paired t-test; p < 0.05 value was considered statistically significant.Results: Nine patients, seven men and two women, with a mean age of 35.77 22.50 (range 8-60) years, were included in the study. In comparison to normal eyes, the colobomatous eyes were statistically found to have lower keratometry values in diopters (43.82 +/- 2.17, 44.46 +/- 1.86; p = 0.040), a greater negative asphericity (Q value) (-0.38 +/- 0.07, -0.22 +/- 0.20; p = 0.042), increased corneal thickness (569.78 +/- 25.42, 537.33 +/- 27.36; p < 0.001), decreased anterior chamber depth (2.50 +/- 0.32, 2.81 +/- 0.50; p = 0.005), a shallower angle (30.51 +/- 10.68, 35.29 +/- 9.99; p = 0.057), higher best-fit sphere (BFS) values of the anterior and posterior corneal surfaces (7.88 +/- 0.39, 7.67 +/- 0.37; p = 0.001; 6.40 +/- 0.26, 6.23 +/- 0.19; p = 0.006), larger pupil diameter (3.48 +/- 0.49, 2.80 +/- 0.34; p = 0.001), smaller horizontal corneal diameter (HCD) (11.06 +/- 0.42; 11.26 +/- 0.45; p = 0.009), and higher value of endothelial cell density (ECD) (3161 +/- 431; 2923 +/- 590; p = 0.031).Conclusion: We have determined that a number of factors such as keratometry values, particularly of the corneal endothelium, are different from those of normal eyes. These differences should be taken into account in the follow-up and treatment of eyes with iris coloboma.