Fine structure of ribosomal RNA. IV. Extraordinary evolutionary conservation in sequences that flank introns in rDNA.
Fine structure of ribosomal RNA. IV. Extraordinary evolutionary conservation in sequences that flank introns in rDNA.
复制标题
核糖体RNA的精细结构。
DOI：
10.1093/nar/8.16.3623
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发表时间：
1980
影响因子：
14.9
通讯作者：
Gerbi,SA
中科院分区：
文献类型：
--
作者：
Gourse,RL;Gerbi,SA
通过杂交和DNA测序，我们在爪蟾rDNA中定义了一个特定的区域，该区域在原生动物四足动物和脊椎动物爪蟾之间非常保守。这个高度保守的区域位于内含子中断四膜虫rDNA的位置[1,2]，尽管我们尚未在基因组或克隆的爪蟾rDNA中检测到内含子。我们已经注意到，与核rDNA内含子侧翼区域对应的序列显示出有趣的互补性，这提示了tRNA-rRNA在蛋白质合成和/或rRNA剪接中的相互作用的可能模型。
By hybridization and DNA sequencing, we have defined a specific region in Xenopus rDNA that is extremely conserved between Tetrshymena, a protozoan, and Xenopus, a vertebrate. This highly conserved region is found at the site where an intron has been shown to interrupt Tetrahymena rDNA [1,2] although we have not detected introns in genomic or cloned Xenopus rDNA. We have noted that the sequences corresponding to nuclear rDNA intron-flanking regions show an intriguing complementarity toThis suggests possible models for tRNA-rRNA interactions in protein synthesis and/or rRNA splicing.