Production of no-carrier-added 64Cu and applications to molecular imaging by PET and PETIS as a biomedical tracer
Production of no-carrier-added 64Cu and applications to molecular imaging by PET and PETIS as a biomedical tracer
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DOI：
10.1007/s10967-008-7443-9
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发表时间：
2009-04-01
影响因子：
1.6
通讯作者：
Ishioka, N. S.
中科院分区：
文献类型：
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作者：
Watanabe, S.;Iida, Y.;Ishioka, N. S.
使用富集的（NiO）-Ni-64靶，通过Ni-64（p，n）Cu-64反应产生铜-64。研究和比较了不同能量质子束在厚靶上产生Cu-64的产额。富集Ni-64的回收率高，方法简单。采用正电子发射断层扫描（PET）和正电子发射示踪剂成像系统（PETIS）进行成像研究。我们在PET和PETIS研究中获得了清晰的图像。本研究结果表明，Cu-64可作为生物医学示踪剂用于动物和植物的分子成像。
Copper-64 was produced by the Ni-64(p, n)Cu-64 reaction using enriched (NiO)-Ni-64 target. We investigated and compared the production yield of Cu-64 for proton beams of various energies by using a thick target. Enriched Ni-64 was recovered with high yield by simple procedures. Imaging studies using positron emission tomography (PET) and positron emitting tracer imaging system (PETIS) were performed. We obtained clear images in PET and PETIS studies. The results of this study indicate that Cu-64 can be utilized as a biomedical tracer for the molecular imaging both in animals and plants.