Evaluation of electrocardiographic and hemodynamic effects of caffeine with acute dosing in healthy volunteers
Evaluation of electrocardiographic and hemodynamic effects of caffeine with acute dosing in healthy volunteers
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DOI：
10.1592/phco.21.5.437.34502
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发表时间：
2001-04-01
期刊：
影响因子：
4.1
通讯作者：
White, CM
中科院分区：
文献类型：
--
作者：
Ammar, R;Song, JC;White, CM
研究目的。评估适量单剂量咖啡因摄入对心电图变量的影响：PR、QRS、QT、QTc 和 RR 间期，以及 QT 和 QTc 间期离散度。还评估了咖啡因对血压和心率的影响。设计。随机、双盲、安慰剂对照、交叉研究。设置。大学药学院。患者。十名 17 岁或以上的健康志愿者。干预。参与者在研究开始前至少 2 天戒除含咖啡因的产品，并被随机指定在不同的日子接受安慰剂或 400 毫克咖啡因。对于每个研究阶段，均进行基线 12 导联心电图 (ECG)，并在摄入研究药物 3 小时后进行后续 12 导联心电图。每次心电图均读取血压读数。测量和主要结果。任何组内或组间心电图变量均未发生显着变化。与基线相比，咖啡因使血压（收缩压 [SBP]/舒张压 [DBP]）从 118 +/- 5/75 +/- 6 mm Hg 升高至 128 +/- 8/77 +/- 7 mm Hg（SBP 和 DBP 分别为 p=0.0022 和 p=0.0368）。给药后，咖啡因组的 SBP 显着高于安慰剂组（128 +/- 8 mm Hg 对比 119 +/- 7 mm Hg，p=0.0174）。结论。健康年轻人适量摄入咖啡因不会严重影响 PR、QRS、QT、QTc 和 RR 间期，或 QT 和 QTc 间期离散度。未接触过咖啡因的受试者在摄入咖啡因 3 小时后收缩压和舒张压持续升高，这表明在临床环境中测定血压需要比建议的戒断咖啡因时间更长的时间。
Study Objective. To evaluate the effects of moderate, single-dose caffeine consumption on electrocardiographic variables: PR, QRS, QT, QTc, and RR intervals, and QT and QTc interval dispersion. Effects of caffeine on blood pressure and heart rate also were evaluated.Design. Randomized, double-blind, placebo-controlled, crossover study.Setting. University school of pharmacy.Patients. Ten healthy volunteers aged 17 years or older.Intervention. Participants abstained from caffeinated products for at least 2 days before the study began and were randomly designated to receive placebo or caffeine 400 mg on various days. For each of the study phases, a baseline 12-lead electrocardiogram (ECG) was performed and a subsequent 12-lead ECG performed 3 hours after ingesting the study drug. Blood pressure readings were taken with each ECG.Measurements and Main Results. No significant changes in any intragroup or intergroup electrocardiographic variables occurred. Caffeine increased blood pressure (systolic blood pressure [SBP]/diastolic blood pressure [DBP]) from 118 +/- 5/75 +/- 6 mm Hg to 128 +/- 8/77 +/- 7 mm Hg versus baseline (p=0.0022 and p=0.0368 for SBP and DBP, respectively). After drug dosing, SBP in the caffeine group was significantly higher than in the placebo group (128 +/- 8 mm Hg versus 119 +/- 7 mm Hg, p=0.0174).Conclusion. Moderate caffeine consumption by healthy young adults does not acutely affect PR, QRS, QT, QTc, and RR intervals, or QT and QTc interval dispersion. Caffeine-naive subjects experienced persistent elevations in SBP and DBP 3 hours after caffeine ingestion, indicating that longer caffeine abstinence than that which is recommended is necessary for blood pressure determination in the clinical setting.