Involvement of sex, strain and age factors in high fat diet-induced obesity in C57BL6J and BALB/cA mice
Involvement of sex, strain and age factors in high fat diet-induced obesity in C57BL6J and BALB/cA mice
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DOI：
10.1538/expanim.56.263
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发表时间：
2007-07-01
影响因子：
2.4
通讯作者：
Uetsuka, Koji
中科院分区：
文献类型：
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作者：
Nishikawa, Satomi;Yasoshima, Akira;Uetsuka, Koji
虽然已经报道了许多肥胖动物模型，但每种模型都具有不同的肥胖特征，因此在选择适合实验目的的动物模型时应谨慎。在这份报告中，我们用高脂饮食（HFD）喂养4周龄（青年）和52周龄（中年）C57 BL/6J（B6）和青年BALB/cA（BALB/c）小鼠9周，并研究肥胖的临床和组织学特征。在BALB/c小鼠中，雄性小鼠的体重和体脂重量比雌性小鼠增加更多，并且具有更高的能量摄入。比较不同品系小鼠的高脂饲料喂养效果，BALB/c雄性小鼠肝脏脂质蓄积量高于B6雄性小鼠。此外，中年B6小鼠的脂肪/体重比和肝脏脂质蓄积比年轻小鼠更多。由此可见，高脂饲料诱导的小鼠肥胖特征受性别、品系和年龄的影响。这些因素可能与性类固醇激素、肝脏脂质代谢和全身代谢有关。本研究为高脂饮食诱导肥胖动物模型的建立提供了基础数据。
Although a number of obesity animal models have been reported, each model possesses different characteristics of obesity, suggesting care should be taken in choosing an animal model suitable for the experimental purpose. In this report, we fed 4-(young) and 52-week-old (middle-aged) C57BL/6J (B6) and young BALB/cA (BALB/c) mice with a high fat diet (HFD) for 9 weeks, and investigated the clinical and histological characteristics of obesity. In BALB/c mice, males gained more body weight and body fat weight and had higher energy intake than females by HFD feeding. Comparing the effect of HFD feeding between the strains of mice, BALB/c male mice accumulated more hepatic lipid than B6 male mice. In addition, middle-aged B6 mice increased the ratio of fat to body weight and hepatic lipid accumulation more than young mice. In conclusion, the characteristics of obesity induced by HFD feeding were influenced by the sex, strain and age of mice. Sex steroid hormones, hepatic lipid metabolism and systemic metabolism might be involved in these factors. The basic data in this study will be useful for the development of animal models of high fat diet-induced obesity.