SYSTEMIC NATURE OF ENDOTHELIAL DYSFUNCTION IN ATHEROSCLEROSIS
SYSTEMIC NATURE OF ENDOTHELIAL DYSFUNCTION IN ATHEROSCLEROSIS
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DOI：
10.1016/0002-9149(95)80017-m
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发表时间：
1995-02-23
影响因子：
2.8
通讯作者：
GANZ, P
中科院分区：
文献类型：
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作者：
ANDERSON, TJ;GERHARD, MD;GANZ, P
血管内皮通过释放一氧化氮等因子，在维持血管舒张、抑制血小板聚集和平滑肌细胞增殖方面发挥着关键作用。大量数据表明，患有动脉粥样硬化或动脉粥样硬化危险因素的患者心外膜冠状动脉的冠状动脉内皮功能异常。这种功能障碍会导致异常的血管收缩和血小板聚集，这可能是导致冠状动脉疾病患者缺血的原因之一。侵入性技术已可用于评估冠状动脉内皮依赖性血管舒张反应。然而，直到最近，人们对外周脉管系统的内皮反应知之甚少，因为评估这种反应的方法还没有现成的。探讨了内皮功能障碍是一个全身过程的假设，并讨论了评估内皮功能的新的无创方法。
Vascular endothelium plays a pivotal role in the maintenance of vasodilation and the inhibition of platelet aggregation and smooth muscle cell proliferation through the release of nitric oxide and other factors. Extensive data have demonstrated abnormalities in coronary endothelial function in the epicardial coronary arteries in patients with atherosclerosis or risk factors for atherosclerosis. This dysfunction leads to abnormal vasoconstriction and platelet aggregation, which likely play a role in producing ischemia In patients with coronary artery disease. Invasive techniques have been available to assess endothelium-dependent vasodilator responses in the coronary arteries. However, until recently little has been known about endothelial responses in the peripheral vasculature, as methods to assess this have not been readily available. The hypothesis that endothelial dysfunction is a systemic process is explored, and new noninvasive methods of assessing endothelial function are discussed.