Increased serum interleukin-8 in patients with early and metastatic breast cancer correlates with early dissemination and survival
Increased serum interleukin-8 in patients with early and metastatic breast cancer correlates with early dissemination and survival
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DOI：
10.1158/1078-0432.ccr-04-0812
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发表时间：
2004-11-01
影响因子：
11.5
通讯作者：
Dirix, LY
中科院分区：
文献类型：
--
作者：
Benoy, IH;Salgado, R;Dirix, LY
目的：探讨血清白细胞介素（IL）-8对转移性乳腺癌患者预后的意义。血清IL-8的预测价值骨髓穿刺液中存在的隐匿性转移性肿瘤细胞进行了评估，在患者可手术和转移性breastcancer.Experimental Design：血清IL-8测定健康对照组，可手术乳腺癌患者，和未经治疗的，进行性转移性乳腺癌患者。在69例可手术或晚期乳腺癌患者中，对骨髓抽吸物中的隐性细胞角蛋白阳性细胞进行了计数。结果：67%（52/77）的晚期乳腺癌患者血清IL-8水平升高。总体而言，乳腺癌患者的这些水平显著高于健康志愿者（P < 0.001）。IL-8水平在患有更晚期疾病的患者中显著增加。血清IL-8升高与临床进程加快、肿瘤负荷增加以及肝脏或淋巴结受累有关。多因素分析表明血清IL-8是复发后生存的独立显著因素。骨髓细胞角蛋白阳性与阴性患者血清IL-8水平差异有显著性（P < 0.04）。结论：血清IL-8水平在乳腺癌患者中升高，并与复发后生存率有独立的预后意义。对隐性细胞角蛋白阳性骨髓细胞之间关系的观察证实了IL-8作为肿瘤细胞播散过程的贡献者的概念。同样，血清IL-8与淋巴结分期的关系值得进一步研究。这些结果进一步扩展了炎症和炎性细胞因子是肿瘤进展的关键组成部分的概念。
Purpose: The prognostic significance of serum interleukin (IL)-8 was evaluated in patients with metastatic breast cancer. The predictive value of serum IL-8 for the presence of occult metastatic tumor cells in bone marrow aspirates was evaluated in patients with operable and metastatic breast cancer.Experimental Design: Serum IL-8 was measured in healthy controls, patients with operable breast cancer, and patients with untreated, progressive metastatic breast cancer. In 69 patients with either operable or advanced breast cancer, occult cytokeratin-positive cells were counted in bone marrow aspirates.Results: Serum IL-8 levels are increased in 67% (52 of 77) of patients with advanced breast cancer. Overall, these levels are significantly higher in patients with breast cancer compared with healthy volunteers (P < 0.001). The IL-8 levels increase significantly in patients with more advanced disease. An elevated serum IL-8 is related to an accelerated clinical course, a higher tumor load, and the presence of liver or lymph node involvement. A multivariate analysis indicates that serum IL-8 is an independent significant factor for postrelapse survival. There was a significant difference between serum IL-8 levels in patients with or without occult cytokeratin-positive bone marrow cells (P < 0.04). Serum IL-8 levels also showed an association with the number of these cells (P < 0.01).Conclusions: Serum IL-8 is increased in patients with breast cancer and has an independent prognostic significance for postrelapse survival. The observations on the relationship between occult cytokeratin-positive bone marrow cells corroborate the concept of IL-8 acting as a contributor to the process of tumor cell dissemination. Similarly, the relationship between serum IL-8 and nodal stage at presentation deserves further study. These results further expand the concept that inflammation and inflammatory cytokines are critical components of tumor progression.