Monocytes link atherosclerosis and cancer.

Monocytes link atherosclerosis and cancer.
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DOI:
10.1002/eji.201141727
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发表时间:
2011-09
影响因子:
5.4
通讯作者:
Swirski, Filip K.
Swirski, Filip K.
中科院分区:
医学3区
文献类型:
--
作者:
Pittet, Mikael J.;Swirski, Filip K.

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从许多方面来看,心血管疾病和癌症有着根本的不同。一方面,动脉粥样硬化是一种由饮食和生活方式驱动的脂质积聚疾病,而癌症是由突变驱动的“内部”攻击。然而,过去20年的研究迫使我们重新评估这种观点。我们正在了解到,除其他因素外,免疫系统对这两种疾病的发展和进展是不可或缺的。它的成分不仅是反应性的,而且还可以协调肿瘤和动脉粥样硬化病变的生长。在这个观点中,我们探讨了作为免疫系统关键成分的单核细胞如何在心血管疾病和癌症之间建立联系。
From many perspectives, cardiovascular diseases and cancers are fundamentally different. On the one hand, atherosclerosis is a disease of lipid accumulation driven by diet and lifestyle, whereas cancer is an attack “from within” driven by mutations. Nevertheless, studies over the last 20 years have forced us to re-evaluate such a view. We are learning that, among other factors, the immune system is indispensable to the development and progression of both diseases. Its components are not only reactive but can also orchestrate both tumor and atherosclerotic lesion growth. In this Viewpoint, we explore how monocytes, which are key constituents of the immune system, forge links between cardiovascular diseases and cancers.
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