Wntless in Wnt secretion: molecular, cellular and genetic aspects.
Wntless in Wnt secretion: molecular, cellular and genetic aspects.
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Wnt 分泌中的 Wntless：分子、细胞和遗传方面。
DOI：
10.1007/s11515-012-1200-8
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发表时间：
2012-12-01
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在整个动物界，Wnt触发的信号转导通路在胚胎发育和组织动态平衡中发挥着重要作用。WNT蛋白被修饰为糖脂蛋白，并作为形态原分泌到细胞外环境中。最近对Wnt蛋白在细胞内运输的研究表明，它的分泌途径受到多层调控。这些发现促使研究人员对进一步研究控制Wnts释放的分子机制，从而控制Wnt信号水平产生了极大的兴趣。这篇综述致力于Wnless，一种可能的G蛋白偶联受体，它将Wnts运送到细胞内进行分泌。在这里，我们重点介绍从最近的细胞、分子和遗传学研究中得出的结论，这些研究肯定了Wnless在Wnt蛋白分泌中的作用。
Throughout the animal kingdom, Wnt-triggered signal transduction pathways play fundamental roles in embryonic development and tissue homeostasis. Wnt proteins are modified as glycolipoproteins and are secreted into the extracellular environment as morphogens. Recent studies on the intracellular trafficking of Wnt proteins demonstrate multiple layers of regulation along its secretory pathway. These findings have propelled a great deal of interest among researchers to further investigate the molecular mechanisms that control the release of Wnts and hence the level of Wnt signaling. This review is dedicated to Wntless, a putative G-protein coupled receptor that transports Wnts intracellularly for secretion. Here, we highlight the conclusions drawn from the most recent cellular, molecular and genetic studies that affirm the role of Wntless in the secretion of Wnt proteins.