Selective supersensitivity to norepinephrine in intimal thickened rabbit aorta.
Selective supersensitivity to norepinephrine in intimal thickened rabbit aorta.
复制标题
兔主动脉内膜增厚对去甲肾上腺素选择性超敏反应。
DOI：
10.1159/000158610
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Hagen,PO
中科院分区：
文献类型：
--
作者：
Makhoul,RG;O'Malley,MK;Mikat,EM;Cole,CW;McCann,RL;Hagen,PO
平滑肌的一个公认的特征是改变其对刺激剂的敏感性的能力。在病变血管和不同的实验条件下，血管平滑肌对多种激动剂的超敏感性已得到证实。已显示动脉粥样硬化的人冠状动脉对组胺超敏感[Ginsburg等人，1984]，而Kalsner和理查兹[1984]发现心脏病患者的血管对组胺和5-羟色胺（5-HT）反应过度。血管超敏性已在各种动物物种中被证明对激动剂如5-羟色胺（5-HT）具有超敏性。
A recognized feature of smooth muscle is the ability to change its sensitivity to a stim ulant. Supersensitivity in vascular smooth muscle has been demonstrated to a wide va riety of agonists in diseased vessels and under differing experimental conditions. Athero sclerotic human coronary arteries have been shown to be supersensitive to histamine [Ginsburg et al., 1984], while Kalsner and Richards [1984] found that vessels from car diac patients were hyperreactive to histamine and 5-hydroxytryptamine (5-HT). Vascular supersensitivity has been demonstrated in various animal species to agonists such as 5-