Transplacental transfer of phenyltins from a pregnant Dall's porpoise (Phocoenoides dalli) to her fetus.
Transplacental transfer of phenyltins from a pregnant Dall's porpoise (Phocoenoides dalli) to her fetus.
复制标题
DOI：
10.1016/j.chemosphere.2006.10.019
复制
发表时间：
2007-02
期刊：
影响因子：
8.8
通讯作者：
Jian Yang;H. Harino;N. Miyazaki
中科院分区：
文献类型：
--
作者：
Jian Yang;H. Harino;N. Miyazaki
首次研究了单苯基锡(MPT)、二苯基锡(DPT)和三苯基锡(TPT)在一种鲸类物种中的母胎转移。母个体受到苯基锡化合物的污染，肌肉、脂肪和肝脏占苯基锡总负荷量的90%。通过胎盘转移证实了两代苯基锡污染。这项研究表明，总苯基锡对大约6个月大的胎儿的转移率为0.29%。与母亲不同，胎肝不能被认为是所有苯基锡研究的靶器官。在约100 kg体重的江豚母体和2.21 kg体重的胚胎中，分别含有约153μg和0.44μg的总苯基锡(TPT，0.38μg；DPT，0.03μg；MPT，0.03μg)。TPT的人体负荷分别占母体和胎儿苯基锡总负荷的91%和86%。
The maternal to fetal transfer of monophenyltin (MPT), diphenyltin (DPT), and triphenyltin (TPT) was investigated for the first time in a cetacean species, a mother–fetus pair of Dall’s porpoises (Phocoenoides dalli) collected off the Sanriku coast, Japan. The mother individual was contaminated by phenyltin compounds, and the muscle, blubber, and liver accounted for 90% of the total phenyltin burden. A two-generation phenyltin contamination via transplacental transfer was demonstrated. This study revealed that the transfer rate was 0.29% for total phenyltins to a fetus of about 6-month-old. Unlike in the mother, the fetal liver could not be considered the target organ for all the phenyltins studied. In a ca. 100kg-weight mother Dall’s porpoise and its fetus of 2.21kg-weight, approximately 153μg (TPT, 139μg; DPT, 9.4μg; MPT, 4.2μg) and 0.44μg of total phenyltins (TPT, 0.38μg; DPT, 0.03μg; MPT, 0.03μg) were found, respectively. The body burden of TPT consisted of 91% and 86% of the total phenyltin burdens in the maternal and fetal bodies, respectively.