Vasoactive intestinal polypeptide (VIP): effects in the eye and on regional blood flows.
Vasoactive intestinal polypeptide (VIP): effects in the eye and on regional blood flows.
复制标题
血管活性肠多肽（VIP）：对眼睛和局部血流的影响。
DOI：
10.1111/j.1748-1716.1984.tb07470.x
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Bill,A
中科院分区：
文献类型：
--
作者：
Nilsson,SF;Bill,A
用标记微球法观察血管活性肠肽（VIP）对白化病家兔局部血流量的影响。静脉注射500 ng VIP/kg B。W.在100秒期间，没有显著改变动脉血压，但引起眼内压（IOP）升高和脉络膜血流量增加35%，而通过前葡萄膜的血流量不受影响。在胰腺、甲状腺和腮腺中观察到最明显的血管舒张。在这些组织中，局部血流量增加超过100%。该剂量VIP产生血管舒张的其他组织是下颌下腺、眼睑、瞬膜、脉络丛和心肌。在大多数组织中，神经节或毒蕈碱阻滞对VIP诱导的血管舒张作用几乎没有或没有影响。前房内注射VIP（1 μg）可使虹膜和睫状体血管舒张，但不影响IOP。VIP对瞳孔大小或血-房水屏障无明显影响。在从开放的涡旋静脉静脉输注VIP，100 ng的直接血流量测定的实验中。kg-1.min-1b. W.，在5分钟内，葡萄膜血管阻力降低了约50%。本研究表明，VIP在许多组织中是一种强效血管扩张剂，其剂量几乎不影响动脉血压，并支持以下观点，即VIP负责面神经刺激引起的眼部非胆碱能血管扩张。
The effect of vasoactive intestinal polypeptide (VIP) on regional blood flows was studied with labeled microspheres in albino rabbits. Intravenous injection of 500 ng VIP/kg b. w. during 100 s did not change the arterial blood pressure significantly, but caused a rise in intraocular pressure (IOP) and an increase in the choroidal blood flow by 35%, while the blood flow through the anterior uvea was unaffected. The most pronounced vasodilation was observed in the pancreas, the thyroid gland and the parotid gland. In these tissues local blood flow increased by more than 100%. Other tissues, in which this dose of VIP produced vasodilation, were the submandibular gland, the eyelids, the nictitating membrane, the choroid plexus and the heart muscle. Ganglionic or muscarinic blockade had little or no effect on the VIP‐induced vasodilation in most of the tissues. Intracameral injection of VIP (1 μg) produced vasodilation in the iris and the ciliary body, but did not affect IOP. VIP had no apparent effect on the pupil size or the blood‐aqueous barrier. In experiments with direct blood flow determination from an opened vortex vein intravenous infusion of VIP, 100 ng. kg‐1.min‐1b. w., during five minutes reduced the uveal vascular resistance by about 50%. This study shows that VIP is a potent vasodilator in many tissues at doses hardly affecting the arterial blood pressure and supports the suggestion, that VIP is responsible for the non‐cholinergic vasodilation in the eye caused by facial nerve stimulation.