The Role of Hedgehog Pathway in Female Cancers.
The Role of Hedgehog Pathway in Female Cancers.
复制标题
刺猬途径在雌性癌症中的作用。
DOI：
10.26502/jcsct.5079089
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Yang Q
中科院分区：
文献类型：
--
作者：
Garcia N;Ulin M;Al-Hendy A;Yang Q
刺猬信号通路（hedgehog pathway，HH）是参与许多生物学事件的关键调节子之一。该通路的功能障碍与包括几种类型的癌症在内的多种疾病有关。我们从公共数据库中收集数据，并进行了一项将HH途径与女性癌症联系起来的全面搜索。此外，我们还综述了靶向HH通路在女性癌症中的临床试验。本文就HH通路的激活及其在乳腺癌、卵巢癌、宫颈癌、子宫内膜癌、子宫平滑肌肉瘤等女性肿瘤中的作用进行综述。综述并讨论了针对HH通路中SMO和GLI的治疗方案。刺猬通路在几种类型的女性癌症中被激活。因此，靶向HH通路可能被认为是女性癌症治疗中公认的治疗选择。
The hedgehog pathway (HH) is one of the key regulators involved in many biological events. Malfunction of this pathway is associated with a variety of diseases including several types of cancers. We collected data from public databases and conducted a comprehensive search linking the HH pathway with female cancers. In addition, we overviewed clinical trials of targeting HH pathway in female cancers. The activation of HH pathway and its role in female cancers, including breast cancer, ovarian cancer, cervical cancer, endometrial cancer, and uterine leiomyosarcoma were summarized. Treatment options targeting SMO and GLI in HH pathway were reviewed and discussed. The hedgehog pathway was shown to be activated in several types of female cancers. Therefore, targeting HH pathway may be considered as a therapeutic option to be acknowledged in the treatment of female cancers.