Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms
Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms
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DOI：
10.1002/ana.10079
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发表时间：
2002-01-01
影响因子：
11.2
通讯作者：
Toda, T
中科院分区：
文献类型：
--
作者：
Momose, Y;Murata, M;Toda, T
我们研究了18个与帕金森病相关的候选基因中的20个单核苷酸多态性。我们发现脑源性神经营养因子（BDNF）基因V66 M多态性的纯合性在帕金森病患者中比在未受影响的对照组中更频繁地发生（chi（2）= 5.46），并证实与UCH-L1基因的SI 8 Y多态性相关。我们的研究结果提供了支持BDNF在帕金森病发病机制中的作用的遗传学证据。
We studied 20 single nucleotide polymorphisms in 18 candidate genes for association with Parkinson's disease. We found that homozygosity for the V66M polymorphism of the brain-derived neurotrophic factor (BDNF) gene occurs more frequently in patients with Parkinson's disease than in unaffected controls (chi(2) = 5.46) and confirmed an association with the SI8Y polymorphism of the UCH-L1 gene. Our results provide genetic evidence supporting a role for BDNF in the pathogenesis of Parkinson's disease.