ARWEN:: a program to detect tRNA genes in metazoan mitochondrial nucleotide sequences
ARWEN:: a program to detect tRNA genes in metazoan mitochondrial nucleotide sequences
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DOI：
10.1093/bioinformatics/btm573
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发表时间：
2008-01-15
期刊：
影响因子：
5.8
通讯作者：
Canback, Bjorn
中科院分区：
文献类型：
--
作者：
Laslett, Dean;Canback, Bjorn
动机：线粒体基因组编码他们自己的转移RNA(TRNAs)。与它们的细菌祖先中的tRNA相比，它们在序列和结构上往往是退化的。这就是为什么目前的tRNA基因预测器程序识别线粒体tRNA基因表现不佳的原因之一。因此，需要一个新的程序来预测这些tRNA。结果：在本研究中，我们介绍了ARWEN软件，该软件可以识别后生动物线粒体核苷酸序列中的tRNA基因。阿尔文检测到了近100个以前注释过的基因。
Motivation: Mitochondrial genomes encode their own transfer RNAs (tRNAs). These are often degenerate in sequence and structure compared to tRNAs in their bacterial ancestors. This is one of the reasons why current tRNA gene predictor programs perform poorly identifying mitochondrial tRNA genes. As a consequence there is a need for a new program with the specific aim of predicting these tRNAs.Results: In this study, we present the software ARWEN that identifies tRNA genes in metazoan mitochondrial nucleotide sequences. ARWEN detects close to 100 of previously annotated genes.