ADP-Ribosylation Factor Like GTPase 4C (ARL4C) augments stem-like traits of glioblastoma cells by upregulating ALDH1A3.
ADP-Ribosylation Factor Like GTPase 4C (ARL4C) augments stem-like traits of glioblastoma cells by upregulating ALDH1A3.
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DOI：
10.7150/jca.45052
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发表时间：
2021
影响因子：
3.9
通讯作者：
Yao XH
中科院分区：
文献类型：
--
作者：
Chen Q;Fu WJ;Tang XP;Wang L;Niu Q;Wang S;Lin Y;Cao MF;Hu R;Wen HY;Wang Y;Zhang X;Yao XH
具有干细胞样特性的胶质瘤细胞对肿瘤的发生、发展和治疗耐药性至关重要。因此，确定调节干细胞样性状的特定因子对于设计新型胶质瘤疗法至关重要。本文中，我们报道了adp -核糖基化因子样GTPase 4C （ARL4C）在胶质瘤干细胞样细胞（GSLCs）中高表达。通过体外球体形成效率和体内肿瘤生长来确定，过表达ARL4C可增加GSLCs。ARL4C通过ALDH1A3诱导肿瘤发生。对325例患者标本的分析表明，与低级别胶质瘤相比，ARL4C在胶质母细胞瘤（GBM）中高表达。此外，胶质瘤中ARL4C的高水平表达与患者的无进展生存期和总生存期较差相关。因此，ARL4C可能作为一种新的预后标志物和GBM的治疗靶点。
Glioma cells with stem cell-like properties are crucial for tumor initiation, progression and therapeutic resistance. Therefore, identifying specific factors in regulating stem-like traits is critical for the design of novel glioma therapeutics. Herein, we reported that ADP-Ribosylation Factor Like GTPase 4C (ARL4C) was highly expressed in glioma stem-like cells (GSLCs). GSLCs, determined by the efficiency of sphere formation in vitro and tumor growth in vivo, was increased by overexpression of ARL4C. ARL4C induced the tumorigenesis through ALDH1A3. Analyses of 325 patient specimens showed that ARL4C was highly expressed in glioblastoma (GBM) as compared with lower grade gliomas. In addition, higher level ARL4C expression in glioma was correlated with poorer progression-free survival and overall survival of patients. Therefore, ARL4C may act as a novel prognostic marker and a therapeutic target for GBM.
影响因子：
2.9
作者：
Cancelas JA
通讯作者：
Cancelas JA