Neural Dynamics of Associative Learning during Human Sleep
Neural Dynamics of Associative Learning during Human Sleep
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DOI：
10.1093/cercor/bhz197
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发表时间：
2020-03-01
期刊：
影响因子：
3.7
通讯作者：
Arzi, Anat
中科院分区：
文献类型：
--
作者：
Canales-Johnson, Andres;Merlo, Emiliano;Arzi, Anat
最近的证据表明，人类可以在睡眠中学习全新的信息。为了阐明睡眠学习的神经动力学基础，我们研究了人类睡眠中嗅觉-嗅觉辨别性联想学习过程中的大脑活动。我们发现，与学习相关的delta和sigma神经变化涉及早期的习得阶段，即新的关联正在形成的阶段。与此相反，学习相关的θ活动出现在学习过程的后期，在音调-气味关联已经建立之后。这些发现表明，在睡眠中学习新的联系是通过慢波、sigma和theta活动之间的动态相互作用发出的。
Recent evidence indicates that humans can learn entirely new information during sleep. To elucidate the neural dynamics underlying sleep-learning, we investigated brain activity during auditory-olfactory discriminatory associative learning in human sleep. We found that learning-related delta and sigma neural changes are involved in early acquisition stages, when new associations are being formed. In contrast, learning-related theta activity emerged in later stages of the learning process, after tone-odor associations were already established. These findings suggest that learning new associations during sleep is signaled by a dynamic interplay between slow-waves, sigma, and theta activity.