Hippocampal Dosimetry Predicts Neurocognitive Function Impairment After Fractionated Stereotactic Radiotherapy for Benign or Low-Grade Adult Brain Tumors
Hippocampal Dosimetry Predicts Neurocognitive Function Impairment After Fractionated Stereotactic Radiotherapy for Benign or Low-Grade Adult Brain Tumors
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DOI：
10.1016/j.ijrobp.2012.11.031
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发表时间：
2013-02-01
影响因子：
7
通讯作者：
Tome, Wolfgang A.
中科院分区：
文献类型：
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作者：
Gondi, Vinai;Hermann, Bruce P.;Tome, Wolfgang A.
目的：前瞻性评价分级立体定向放疗（FSRT）治疗良性或低级别成人脑肿瘤时海马剂量与长期神经认知功能（NCF）损害的关系。方法和材料：根据机构实践，采用FSRT治疗成人良性或低级别成人脑肿瘤。没有人试图放过海马体。在一项前瞻性临床试验中，在基线和18个月的随访中进行了NCF检测。基于回归的标准化z分数通过使用在相同测试-重测试间隔评估的相似健康对照个体来计算。NCF损伤定义为z分
Purpose: To prospectively evaluate the association between hippocampal dose and long-term neurocognitive function (NCF) impairment for benign or low-grade adult brain tumors treated with fractionated stereotactic radiotherapy (FSRT).Methods and Materials: Adult patients with benign or low-grade adult brain tumors were treated with FSRT per institutional practice. No attempt was made to spare the hippocampus. NCF testing was conducted at baseline and 18 months follow-up, on a prospective clinical trial. Regression-based standardized z scores were calculated by using similar healthy control individuals evaluated at the same test-retest interval. NCF impairment was defined as a z score