Simultaneous spectrophotometric determination of rutin, quercetin and ascorbic acid in drugs using a Kalman Filter approach
Simultaneous spectrophotometric determination of rutin, quercetin and ascorbic acid in drugs using a Kalman Filter approach
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DOI：
10.1016/s0731-7085(99)00048-5
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发表时间：
1999-06-01
影响因子：
3.4
通讯作者：
Habib, IHI
中科院分区：
文献类型：
--
作者：
Hassan, HNA;Barsoum, BN;Habib, IHI
本文提出了一种用紫外分光光度法分析抗毛细脆性药物芦丁、槲皮素和抗坏血酸的混合物和片剂或软胶囊的光谱严重重叠的方法。该方法基于正交实验设计（即一次仅含一种组分的标准品溶液）或非正交实验设计（即含一种以上组分的标准品溶液）的卡尔曼滤波器校准。在此校准之后，定量测定合成混合物或口服剂量中浓度范围为2-10 μ g ml（-1）的两组分和三组分混合物。报告了结果的统计分析。(C)1999 Elsevier Science B. V.保留所有权利。
A W-spectrophotometric analysis of severely overlapped spectra yielded by anti-capillary fragility pharmaceutical materials, viz. rutin, quercetin and ascorbic acid, in authentic mixtures and in tablets or soft elastic capsules was proposed. The method was based on Kalman Filter calibration of either orthogonal experimental design, i.e. standard solutions containing only one component at a time, or non-orthogonal experimental design, i.e. standard solutions containing more than one component. This calibration was followed by quantitative determinations of two- and three-component mixtures in synthetic mixtures or in oral dosages within the concentration range 2-10 mu g ml(-1). A statistical analysis of the results was reported. (C) 1999 Elsevier Science B.V. All rights reserved.