Thinning of cervical nerve roots and peripheral nerves in ALS as measured by sonography
Thinning of cervical nerve roots and peripheral nerves in ALS as measured by sonography
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DOI：
10.1016/j.clinph.2014.01.033
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发表时间：
2014-09-01
影响因子：
4.7
通讯作者：
Kaji, Ryuji
中科院分区：
文献类型：
--
作者：
Nodera, Hiroyuki;Takamatsu, Naoko;Kaji, Ryuji
目的：肌萎缩侧索硬化（ALS）的一个重要特征是运动神经轴突的进行性萎缩和缺失。有限的超声数据可用于潜在的检测周围神经和神经根的萎缩在ALS.Methods：患者无论是明确的或可能的ALS和对照组进行了超声评价的颈根（C5，C6和C7）和周围神经（正中神经和尺神经）的权利。这些直径和横截面积（C6，正中，尺神经）进行了compared.Results：直径和横截面积始终小于ALS比对照组。超声参数与疾病严重程度、病程、年龄或性别之间无相关性。整体的敏感性和特异性往往是更大的颈神经根比周围nerves.Conclusions：这项研究表明，萎缩的颈神经根和周围神经的ALS检测超声。颈神经根可能更适合检测运动轴突损失比周围nerve.Significance：超声评价的神经根和周围神经可能是一个有用的疾病标志物在ALS，以确认诊断和潜在的监测疾病进展。(C)2014年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: Progressive atrophy and loss of motor axons is a hallmark of amyotrophic lateral sclerosis (ALS). Limited sonographic data are available on potential detection of atrophy of peripheral nerves and nerve roots in ALS.Methods: Patients with either definite or probable ALS and control subjects underwent sonographic evaluation of the cervical roots (C5, C6, and C7) and peripheral nerves (median and ulnar nerves) on the right. These diameters and cross-sectional areas (C6, median, and ulnar nerves) were compared.Results: The diameters and cross-sectional areas were consistently smaller in ALS than in controls. No correlation was present between the sonographic parameters and the disease severity, disease duration, age, or gender. The overall sensitivity and specificity tended to be greater in the cervical nerve roots than in the peripheral nerves.Conclusions: This study shows atrophy of cervical nerve roots and peripheral nerves in ALS detected by sonography. Cervical nerve roots might be more appropriate to detect motor axon loss than peripheral nerves.Significance: Sonographic evaluation of nerve roots and peripheral nerves may be a useful disease marker in ALS to confirm the diagnosis and to potentially monitor the disease progression. (C) 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.