EVIDENCE THAT INACTIVATED ORAL CHOLERA VACCINES BOTH PREVENT AND MITIGATE VIBRIO-CHOLERAE O1 INFECTIONS IN A CHOLERA-ENDEMIC AREA
EVIDENCE THAT INACTIVATED ORAL CHOLERA VACCINES BOTH PREVENT AND MITIGATE VIBRIO-CHOLERAE O1 INFECTIONS IN A CHOLERA-ENDEMIC AREA
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DOI：
10.1093/infdis/166.5.1029
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发表时间：
1992-11-01
影响因子：
6.4
通讯作者：
HARRIS, JR
中科院分区：
文献类型：
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作者：
CLEMENS, JD;SACK, DA;HARRIS, JR
在孟加拉国农村进行的一项随机、安慰剂对照的口服B亚单位灭活全细胞（BS-WC）和仅灭活全细胞（WC）灭活霍乱疫苗现场试验中，在接种后的第一年对选定社区进行积极监测，在3285名三剂接种者中发现127例霍乱弧菌O1感染。对于每种疫苗，对有症状感染的保护效力（57%,BS-WC, P < 0.05; 58%， WC, P < 0.05）都大于对无症状感染的保护效力（46%,BS-WC, P < 0.05; 32%， WC, P = 0.09），并且对经典和El - Tor生物型的每种感染级别都有保护作用。尽管疫苗对有症状感染的保护作用在幼儿和老年人中都很明显，但只有在50至50岁接种疫苗的人才能预防无症状感染。这些结果表明，灭活口服疫苗既可以防止霍乱弧菌O1在肠道定植，又可以中断已建立的感染的致病顺序。
In a randomized, placebo-controlled field trial of B subunit-killed whole cell (BS-WC) and killed whole cell only (WC) inactivated oral cholera vaccines in rural Bangladesh, active surveillance of selected neighborhoods during the first year after vaccination identified 127 Vibrio cholerae O1 infections among 3285 three-dose recipients. For each vaccine, protective efficacy was greater against symptomatic (57%, P < .05 for BS-WC; 58%, P < .05 for WC) than against asymptomatic infections (46%, P < .05 for BS-WC; 32%, P = .09 for WC), and protection against each grade of infection was demonstrable for both the classical and El Tor biotypes. Although vaccine protection against symptomatic infections was evident in both young children and older persons, only persons vaccinated at age > 5 years were protected against asymptomatic infections. These results suggest that the inactivated oral vaccines acted both to protect against intestinal colonization by V. cholerae O1 and to interrupt the pathogenic sequence of established infections.