[Cryptosporidium diarrhea developing in two Japanese adults--one in AIDS and the other in a normal host. Research Group for Infectious Enteric Diseases, Japan].
[Cryptosporidium diarrhea developing in two Japanese adults--one in AIDS and the other in a normal host. Research Group for Infectious Enteric Diseases, Japan].
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[两名日本成年人出现隐孢子虫腹泻——一名患有艾滋病，另一名患有正常宿主。
DOI：
10.11150/kansenshogakuzasshi1970.65.1614
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
S. Uni
中科院分区：
文献类型：
--
作者：
G. Masuda;M. Negishi;A. Ajisawa;T. Yamaguchi;T. Tajima;S. Tamagawa;Y. Maeda;H. Ohtomo;I. Kimata;S. Uni
病例一：一名中年男同性恋者于1986年在欧洲国家逗留约5个月期间患上艾滋病，并伴有卡氏肺孢子虫肺炎(PCP)和食道念珠菌病，1987年被转移到东京都Komagome医院。他还被诊断出患有隐孢子虫病，在被诊断为PCP一个月后出现轻度腹泻。螺旋霉素成功地治疗了腹泻。在被转移到东京都Komagome医院时，他发烧，但没有腹泻。血清HIV、TPHA均阳性，外周血淋巴细胞亚群T4a明显降低。转院后第13天，出现水样腹泻。从17日住院日采集的粪便中检出隐孢子虫卵囊。患者于入院第38天死于大肠杆菌败血症。尸检发现隐孢子虫感染广泛分布在胃、回肠、胆汁和胰管。病例二：女性，31岁，以前健康，每天出现5次粘液性大便。尽管使用了洛哌丁胺，但在接下来的几天里，粘液继续通过，每天增加到20次，并在发病后第4天出现粘液至水样腹泻，伴有轻微的腹部痉挛和恶心。在生病的第6天，她去了东京都Komagome医院。她否认与宠物有密切接触，也否认与任何出现腹泻症状的人有接触。她最近没有在东京以外的任何地方旅行的历史。经检查，她看起来是一个健康的女人，只是腹部略有膨胀，右上腹有局限性压痛。
Case I: A middle-age homosexual male developed AIDS with Pneumocystis carinii pneumonia (PCP) and esophageal candidiasis in 1986 during his stay in an European country about five months prior to transfer to Tokyo Metropolitan Komagome Hospital, Tokyo, in 1987. He was also diagnosed as having cryptosporidiosis presenting with mild diarrhea a month following the diagnosis of PCP. Diarrhea was successfully treated with spiramycin. On transfer to Tokyo Metropolitan Komagome Hospital, he was febrile but had no diarrhea. Serum HIV and TPHA were positive and his blood lymphocyte subset T4a was markedly decreased. On the 13th day after transfer to the hospital, watery diarrhea appeared. Cryptosporidium oocysts were detected from the feces taken on the 17th hospital day. The patient died of Escherichia coli septicemia on the 38th hospital day. Autopsy finding yielded Cryptosporidium infection widely spread over the stomach, ileum, bile and pancreatic ducts. Case II: A 31-year-old previously healthy female presented with abrupt onset of mucous stool five times daily. Mucous passage continued on the subsequent days despite administration of loperamide, and the passage increased to 20 times daily with mucous to watery diarrhea associated with mild abdominal cramps and nausea on the 4th day after onset of illness. On the 6th day of illness, she visited Tokyo Metropolitan Komagome Hospital. She denied close contact with pet animals or contact with any person presenting diarrhea. She had no recent history of travelling anywhere outside Tokyo. On examination she was an apparently healthy woman except for a slightly distended abdomen with localized tenderness in the right upper quadrant.(ABSTRACT TRUNCATED AT 250 WORDS)