The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice
The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice
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DOI：
10.1016/s1521-6616(02)00054-2
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发表时间：
2003-04-01
影响因子：
8.6
通讯作者：
Lynch, KR
中科院分区：
文献类型：
--
作者：
Yang, ZD;Chen, M;Lynch, KR
FrY 720是一种新型的免疫调节药物，来源于真菌鞘氨醇类似物ISP-1（myriocin）。FTY 720引起淋巴细胞从循环到次级淋巴组织的重新分布。I型糖尿病是由胰岛中产生胰岛素的胰腺0细胞的细胞介导的破坏引起的自身免疫性疾病。事实上，单核细胞对胰岛的局部浸润是1型糖尿病的标志。基于FTY 720的作用和疾病进展中细胞浸润的参与，我们测试了FTY 720在糖尿病易感的非肥胖糖尿病（NOD）小鼠中预防自身免疫性糖尿病的能力。我们发现用FrY 720治疗完全防止NOD小鼠发展自身免疫性糖尿病。FTY 720处理的动物显示循环淋巴细胞数量减少和胰岛细胞浸润急剧减少。这些结果表明，FrY 720可能有效地预防自身免疫性糖尿病或减缓其进展。(C)2003 Elsevier Science（美国）。All rights reserved.
FrY720 is a novel immune regulatory drug derived from the fungal sphingosine analog ISP-1 (myriocin). FTY720 causes a redistribution of lymphocytes from circulation to secondary lymphoid tissues. Type I diabetes is an autoimmune disorder caused by cellular-mediated destruction of insulin-producing pancreatic 0 cells in the islets of Langerhans. Indeed, local infiltration of islets by mononuclear cells is the hallmark of Type 1 diabetes. Based on both FTY720's action and the involvement of cellular infiltration in the disease progression, we tested FTY720 for its ability to prevent autoimmune diabetes in diabetes-prone, nonobese diabetic (NOD) mice. We found that treatment with FrY720 completely prevented NOD mice from developing autoimmune diabetes. The FTY720-treated animals showed both reduced numbers of circulating lymphocytes and sharply diminished cellular infiltration of pancreatic islets. These results suggest that FrY720 may be effective in prevention of autoimmune diabetes or in slowing its progression. (C) 2003 Elsevier Science (USA). All rights reserved.