Human acupuncture points mapped in rats are associated with excitable muscle/skin-nerve complexes with enriched nerve endings
Human acupuncture points mapped in rats are associated with excitable muscle/skin-nerve complexes with enriched nerve endings
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DOI：
10.1016/j.brainres.2004.04.009
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发表时间：
2004-06-25
期刊：
影响因子：
2.9
通讯作者：
Xie, YK
中科院分区：
文献类型：
--
作者：
Li, AH;Zhang, JM;Xie, YK
作为我们正在进行的针灸神经机制的调查的一部分，我们试图在大鼠后肢传入神经末梢的分布与穴位（AP）。从外周神经获取Aalpha/Abeta/Adelta纤维的体内细胞外微丝记录，以搜索皮肤或肌肉中具有神经末梢或感受野（RF）的单位。在后肢的比例图上标记每个识别单元的RF位置。利用逆行性刺激诱发的伊文思蓝外渗来绘制皮肤或肌肉中C纤维的RF。结果表明，无论是A-和C-纤维，RF的分布与AP密切相关。在皮肤中，RF集中在AP的位置或沿着经络轨道。类似地，大多数肌肉感觉受体位于肌肉中的AP。我们的研究结果强烈表明，人类的AP可能是可兴奋的肌肉/皮肤神经复合体，具有高密度的神经末梢。(C)2004 Elsevier B. V.保留所有权利。
As part of our ongoing investigation into the neurological mechanisms of acupuncture, we have tried to correlate the distribution of afferent nerve endings with acupuncture points (AP) in the rat hind limbs. In vivo extracellular microfilament recordings of Aalpha/Abeta/Adelta fibers were taken from peripheral nerves to search for units with nerve endings or receptive fields (RF) in the skin or the muscles. The location of the RFs for each identified unit was marked on scaled diagrams of the hind limb. Noxious antidromic stimulation-induced Evans blue extravasation was used to map the RFs of C-fibers in the skin or muscles. Results indicate that, for both A- and C-fibers, the distribution of RFs was closely associated with the APs. In the skin, the RFs concentrate either at the sites of APs or along the orbit of meridian channels. Similarly, the majority of sarcous sensory receptors are located at the APs in the muscle. Results from our studies strongly suggest that APs in humans may be excitable muscle/skin-nerve complexes with high density of nerve endings. (C) 2004 Elsevier B.V. All rights reserved.