Thalidomide therapy for recalcitrant systemic onset juvenile rheumatoid arthritis
Thalidomide therapy for recalcitrant systemic onset juvenile rheumatoid arthritis
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DOI：
10.1067/mpd.2002.120835
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发表时间：
2002-01-01
影响因子：
5.1
通讯作者：
Onel, KB
中科院分区：
文献类型：
--
作者：
Lehman, TJA;Striegel, KH;Onel, KB
对非甾体类抗炎药无反应的全身性幼年类风湿性关节炎可以用皮质类固醇进行控制，但这些药物具有显着的副作用。我们报告了 2 名患有全身性幼年类风湿性关节炎的类固醇依赖性儿童，他们对多种非类固醇抗炎药（甲氨蝶呤、硫唑嘌呤、环孢素和依那西普）没有反应。两个孩子在沙利度胺治疗后都有显着改善。
Systemic onset juvenile rheumatoid arthritis unresponsive to nonsteroidal anti-inflammatory drugs may be controlled with corticosteroids, but these drugs have significant side effects. We report 2 steroid-dependent children with systemic onset juvenile rheumatoid arthritis who did not respond to multiple nonsteroidal anti-inflammatory drugs, methotrexate, azathioprine, cyclosporine, and etanercept. Both children had significant improvement with thalidomide therapy.