A neurobehavioral study of current and former welders exposed to manganese
A neurobehavioral study of current and former welders exposed to manganese
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DOI：
10.1016/j.neuro.2007.08.014
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发表时间：
2008-01-01
期刊：
影响因子：
3.4
通讯作者：
Chashchin, Valery
中科院分区：
文献类型：
--
作者：
Ellingsen, Dag G.;Konstantinov, Roman;Chashchin, Valery
本文研究了96名电焊工的神经行为功能。电焊烟尘（空气-Mn）中锰（Mn）的几何平均浓度为121 μ g/m3（范围为7-2322），其个体平均值为连续两天的采样值。他们与96名年龄匹配的参考对象进行了比较。全血（B-Mn）中Mn的算术平均（AM）浓度为8.6 μ g/L，而参比品中为6.9 μ g/L。数字符号和手指敲击测试分数和硼锰和空气锰，分别观察之间的关联。暴露于最高空气锰浓度（GM 423 μ g/m（3）范围204-2322）的焊工与年龄匹配的参照物相比，手指敲击测试得分在统计学上显著较差。当与年龄匹配的参照物（AM B-Mn 7.5 μ g/L）相比时，具有最高AM B-Mn浓度（12.6 μ g/L）的焊工在数字符号测试中的得分在统计学上显著较差。同样的神经行为测试组合被应用于27名被诊断为患有焊接相关锰中毒并获得经济补偿的患者。他们在诊断时的平均年龄为44.9岁（范围34-51岁），在本研究之前平均年龄为5.8岁。他们从事焊工工作的时间平均为23.1年（15-30年不等）。受影响最大的神经行为功能与受损的手指敲击速度和凹槽钉板性能相关。患者的手震颤没有改变，如CATALYST系统所评估的，而少数受试者有明显的震颤，如静态稳定性测试所评估的。(c)2007爱思唯尔公司All rights reserved.
Neurobehavioral functions were studied in 96 welders currently exposed to the geometric mean (GM) concentration of 121 mu g/m(3) (range 7-2322) manganese (Mn) in welding fume (air-Mn) based on the individual mean from two successive days of sampling. They were compared to 96 age-matched referents. The arithmetic mean (AM) concentration of Mn in whole blood (B-Mn) was 8.6 mu g/L versus 6.9 mu g/L in the referents. Associations between the Digit Symbol and Finger Tapping test scores and B-Mn and air-Mn, respectively, were observed. The welders exposed to the highest air-Mn concentrations (GM 423 mu g/m(3) range 204-2322) had statistically significantly poorer Finger Tapping test score as compared to their age-matched referents. The welders with the highest AM concentration of B-Mn (12.6 mu g/L) scored statistically significantly poorer on the Digit Symbol test when compared to the age-matched referents (AM B-Mn 7.5 mu g/L). The same neurobehavioral test battery was applied to 27 patients diagnosed, and financially compensated, as having welding related manganism. They were on average 44.9 (range 34-51) years old at the time of diagnosis, which on average was 5.8 years prior to this study. They had worked as welders for 23.1 years on average (range 15-30). The most affected neurobehavioral functions were associated with impaired Finger Tapping speed and Grooved Pegboard performance. The patients had no alterations in hand tremor as assessed by the CATSYS system, while a few subjects had noticeable tremor as assessed by the Static Steadiness test. (c) 2007 Elsevier Inc. All rights reserved.