MYOGLOBIN FUNCTION IN EXERCISING SKELETAL-MUSCLE
MYOGLOBIN FUNCTION IN EXERCISING SKELETAL-MUSCLE
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DOI：
10.1126/science.7071598
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
COLE, RP
中科院分区：
文献类型：
--
作者：
COLE, RP
短期用H2O2灌注离体犬腓肠肌-跖肌，可减少稳态肌肉耗氧量和等长张力的产生。H2O2将细胞内肌红蛋白转化为不能与O2结合的产物，但对神经肌肉传递或线粒体氧化磷酸化没有有害影响。功能性细胞内肌红蛋白在维持骨骼肌运动时的氧气消耗和张力产生方面是重要的。
Short-term perfusion of the isolated dog gastrocnemius-plantaris muscle with H2O2 resulted in a decrease in steady-state muscle O2 consumption and isometric tension generation. H2O2 converted intracellular myoglobin to products incapable of combination with O2, but had no deleterious effect on neuromuscular transmission or on mitochondrial oxidative phosphorylation. Functional intracellular myoglobin is important in maintaining O2 consumption and tension generation in exercising skeletal muscle.