Increased motivation for self-administered cocaine after escalated cocaine intake
Increased motivation for self-administered cocaine after escalated cocaine intake
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DOI：
10.1097/00001756-200312020-00019
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发表时间：
2003-12-01
期刊：
影响因子：
1.7
通讯作者：
Markou, A
中科院分区：
文献类型：
--
作者：
Paterson, NE;Markou, A
可卡因自我给药的升级被假设为涉及消费可卡因的动机增加。本研究确定了递增可卡因自我管理的大鼠可卡因剂量反应函数的影响下，渐进的比例计划。允许两组大鼠在固定比例时间表下自我施用可卡因，每天持续1小时（ShA; n = 7）或6小时（LgA; n = 6）。然后，允许受试者按照递增比例方案自我给予5剂可卡因（0、0.031、0.063、0.125和0.25 mg/输注）。与ShA组相比，LgA组的剂量-反应函数向上移动。总之，目前的数据表明，可卡因自我管理的升级与自我管理可卡因的激励价值显着增加。
Escalation in cocaine self-administration is hypothesized to involve increased motivation to consume cocaine. The present study determined the effects of escalated cocaine self-administration in rats on the cocaine dose-response function under a progressive ratio schedule. Two groups of rats were allowed to self-administer cocaine under a fixed ratio schedule, for 1 h (ShA; n = 7) or 6 h (LgA; n = 6) per day. The subjects were then allowed to self-administer five doses of cocaine (0, 0.031, 0.063, 0.125 and 0.25 mg/infusion) under a progressive ratio schedule. The dose-response function was shifted upwards in the LgA compared to the ShA group. In conclusion, the present data suggest that escalation in cocaine self-administration is associated with a significant increase in the incentive motivational value of self-administered cocaine.