Prognostic features in mucoepidermoid carcinoma of major salivary glands with emphasis on tumour histologic grading
Prognostic features in mucoepidermoid carcinoma of major salivary glands with emphasis on tumour histologic grading
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DOI：
10.1111/his.12488
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发表时间：
2014-12-01
期刊：
影响因子：
6.4
通讯作者：
Ganly, Ian
中科院分区：
文献类型：
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作者：
Katabi, Nora;Ghossein, Ronald;Ganly, Ian
目的比较粘液表皮样癌（MEC）的不同分级系统，并确定最可靠和客观的组织病理学特征预测outcome.Methods和results 72例确诊为MEC进行了细致的组织病理学复查。72例中20例（28%）最初误诊为MEC，其中16例误诊为高分级（HG）。在52例确诊的MEC中，中位随访时间（FU）为59个月。有丝分裂（4/10高倍视野）、坏死、多形性、局灶性角化、结缔组织增生和淋巴结转移与不良疾病特异性生存（DSS）和无复发生存（RFS）相关（P
AimsTo compare the different grading systems of mucoepidermoid carcinoma (MEC) and identify the most reliable and objective histopathologic features predictive of outcome.Methods and resultsSeventy-two cases diagnosed as MEC were subjected to a meticulous histopathologic re-review. 20 of 72 (28%) cases were originally misdiagnosed as MEC including 16 as high grade (HG). Among the 52 confirmed MEC, median follow up (FU) was 59months. Mitosis (4/10 High Power Fields), necrosis, pleomorphism, focal keratinization, desmoplasia, and lymph node metastasis were associated with adverse disease specific survival (DSS) and recurrence free survival (RFS) (P