Plasmonic polymers with strong chiroptical response for sensing molecular chirality
Plasmonic polymers with strong chiroptical response for sensing molecular chirality
复制标题
具有强手性光学响应的等离激元聚合物，用于传感分子手性
DOI：
10.1039/c5nr01966d
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发表时间：
2015
期刊：
影响因子：
6.7
通讯作者：
Zhang Xiangdong
中科院分区：
文献类型：
--
作者：
Zhai Dawei;Wang Peng;Wang Rong-Yao;Tian Xiaorui;Ji Yinglu;Zhao Wenjing;Wang Luming;Wei Hong;Wu Xiaochun;Zhang Xiangdong
我们报告的手性光学转移和放大效应观察到的等离子体聚合物组成的非手性金纳米棒单体连接的半胱氨酸手性分子在一个端到端的方式。开发了一种用于控制等离子体聚合物中基于热点的圆二色性（CD）活性位点的新策略，以实现以受控方式定制和可再现的手性光学活性。我们发现，通过调节相邻纳米棒之间的键角和线性等离子体聚合物中的聚合度，紫外光谱区域中的弱分子手性可以通过可见/近红外区域中的诱导CD响应放大两个数量级以上。我们证明，这种等离子体聚合物不仅可以用于提供用于识别分子身份的拉曼“指纹”信息，而且还可以用于（i）以少量水平解析半胱氨酸分子的对映体对，以及（ii）定量手性分析物的对映体纯度的CD签名。手性响应等离子体聚合物的手性分析可能在生物科学和生物医学中找到重要的应用。
We report on the chiroptical transfer and amplification effect observed in plasmonic polymers consisting of achiral gold nanorod monomers linked by cysteine chiral molecules in an end-to-end fashion. A new strategy for controlling the hot spots based circular dichroism (CD)-active sites in plasmonic polymers was developed to realize tailored and reproducible chiroptical activity in a controlled way. We showed that by regulating the bond angles between adjacent nanorods and the degree of polymerization in the linear plasmonic polymer, weak molecular chirality in the ultraviolet spectral region can be amplified by more than two orders of magnitude via the induced CD response in the visible/near infrared region. We demonstrate that this plasmonic polymer can be used to provide not only the Raman “fingerprint” information for identifying the molecular identity but also the CD signatures for (i) resolving the enantiomeric pairs of cysteine molecules at a small quantity level, and (ii) quantifying the enantiomeric purity of the chiral analytes. Chiral analyses by chiroptically responsive plasmonic polymers may find important applications in bioscience and biomedicine.