Chemical metabolomics for investigating the protective effectiveness of Acanthopanax senticosus Harms leaf against acute promyelocytic leukemia.
Chemical metabolomics for investigating the protective effectiveness of Acanthopanax senticosus Harms leaf against acute promyelocytic leukemia.
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化学代谢组学用于研究肝硬化延髓的保护性有效性，危害叶片对急性前临床白血病的叶子。
DOI：
10.1039/c8ra01029c
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发表时间：
2018-03-26
期刊：
影响因子：
3.9
通讯作者：
Wang, Xi-Jun
中科院分区：
文献类型：
--
作者：
Han, Yue;Zhang, Ai-Hua;Zhang, Ying-Zhi;Sun, Hui;Meng, Xiang-Cai;Wang, Xi-Jun
Recent advances in the study of high-throughput metabolomics combined with high-resolution mass spectrometry have accelerated our understanding of the efficacy, mechanisms, and application of natural products. In this study, we have used chemical metabolomics to investigate and discover small molecule metabolites for the potential mechanism of Acanthopanax senticosus Harms leaf (ASL) against acute promyelocytic leukemia (APL). Based on high-throughput metabolomics, the underlying biomarker was found by combining chromatography coupled with quadrupole time-of-flight mass spectrometry with multivariate data analysis. The protective effect of ASL was dissected using biochemical indicators, pathology sections, immunohistochemistry, and multivariate analysis. Furthermore, 13 potential biomarkers associated with the pathway of sugar metabolism, amino-acid metabolism, nucleotide metabolism, and the metabolism of arachidonic acid were identified from serum samples. This study would help to understand chemical metabolomics for investigating the anti-APL effectiveness of ASL. We have used chemical metabolomics to investigate and discover small molecule metabolites for the potential mechanism of Acanthopanax senticosus Harms leaf (ASL) against acute promyelocytic leukemia (APL).
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影响因子：
4
作者：
Liang B;Zheng Z;Shi Y;Chen J;Hu X;Qian H;Shen Z;Jiang S;Yu K;Feng J
通讯作者：
Feng J
影响因子：
--
作者：
Atashrazm F;Lowenthal RM;Dickinson JL;Holloway AF;Woods GM
通讯作者：
Woods GM
影响因子：
50.3
作者：
Timmerman LA;Holton T;Yuneva M;Louie RJ;Padró M;Daemen A;Hu M;Chan DA;Ethier SP;van 't Veer LJ;Polyak K;McCormick F;Gray JW
通讯作者：
Gray JW
影响因子：
7.4
作者：
Gul, Saima;Ahmed, Sagheer;Zia-Ul-Haq, Muhammad
通讯作者：
Zia-Ul-Haq, Muhammad
DOI：
10.4084/mjhid.2011.033
发表时间：
2011-01-01
影响因子：
3.2
作者：
Jeddi, Ramzi;Ghedira, Hela;Meddeb, Balkis
通讯作者：
Meddeb, Balkis